Genomic knockout of endogenous canine P-Glycoprotein in wild-type, human P-Glycoprotein and human BCRP transfected MDCKII cell lines by Zinc Finger Nucleases
To investigate whether it is possible to specifically suppress the expression and function of endogenous canine P-glycoprotein (cPgp) in Madin-Darby canine kidney type II cells (MDCKII) transfected with hPGP and breast cancer resistance protein (hBCRP) by zinc finger nuclease (ZFN) producing sequenc...
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| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2015
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| In: |
Pharmaceutical research
Year: 2014, Volume: 32, Issue: 6, Pages: 2060-2071 |
| ISSN: | 1573-904X |
| DOI: | 10.1007/s11095-014-1599-5 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11095-014-1599-5
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| Author Notes: | Dominik Gartzke, Jürgen Delzer, Loic Laplanche, Yasuo Uchida, Yutaro Hoshi, Masanori Tachikawa, Tetsuya Terasaki, Jens Sydor, Gert Fricker |
MARC
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| 245 | 1 | 0 | |a Genomic knockout of endogenous canine P-Glycoprotein in wild-type, human P-Glycoprotein and human BCRP transfected MDCKII cell lines by Zinc Finger Nucleases |c Dominik Gartzke, Jürgen Delzer, Loic Laplanche, Yasuo Uchida, Yutaro Hoshi, Masanori Tachikawa, Tetsuya Terasaki, Jens Sydor, Gert Fricker |
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| 520 | |a To investigate whether it is possible to specifically suppress the expression and function of endogenous canine P-glycoprotein (cPgp) in Madin-Darby canine kidney type II cells (MDCKII) transfected with hPGP and breast cancer resistance protein (hBCRP) by zinc finger nuclease (ZFN) producing sequence specific DNA double strand breaks. | ||
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