Mechanobiology of leader-follower dynamics in epithelial cell migration
Collective cell migration is fundamental to biological form and function. It is also relevant to the formation and repair of organs and to various pathological situations, including metastatic propagation of cancer. Technological, experimental, and computational advancements have allowed the researc...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 July 2020
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| In: |
Current opinion in cell biology
Year: 2020, Volume: 66, Pages: 97-103 |
| ISSN: | 1879-0410 |
| DOI: | 10.1016/j.ceb.2020.05.007 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ceb.2020.05.007 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0955067420300727 
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| Author Notes: | Medhavi Vishwakarma, Joachim P. Spatz and Tamal Das |
| Summary: | Collective cell migration is fundamental to biological form and function. It is also relevant to the formation and repair of organs and to various pathological situations, including metastatic propagation of cancer. Technological, experimental, and computational advancements have allowed the researchers to explore various aspects of collective migration, spanning from biochemical signalling to inter-cellular force transduction. Here, we summarize our current understanding of the mechanobiology of collective cell migration, limiting to epithelial tissues. On the basis of recent studies, we describe how cells sense and respond to guidance signals to orchestrate various modes of migration and identify the determining factors dictating leader-follower interactions. We highlight how the inherent mechanics of dense epithelial monolayers at multicellular length scale might instruct individual cells to behave collectively. On the basis of these findings, we propose that mechanical resilience, obtained by a certain extent of cell jamming, allows the epithelium to perform efficient collective migration during wound healing. |
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| Item Description: | Gesehen am 25.11.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1879-0410 |
| DOI: | 10.1016/j.ceb.2020.05.007 |