Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer
The expression of 14 individual and two groups of tumor antigens was characterized for colorectal carcinoma by RT-PCR using 26 colorectal carcinoma specimens, eight cell lines, six samples of patients with inflammatory bowl diseases, and nine specimens from different locations of an individual patie...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 January 2004
|
| In: |
Cancer letters
Year: 2004, Jahrgang: 208, Heft: 2, Pages: 197-206 |
| ISSN: | 1872-7980 |
| DOI: | 10.1016/j.canlet.2003.11.021 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.canlet.2003.11.021 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0304383503008115 
|
| Verfasserangaben: | Axel Gerhardt, Dirk Usener, Michael Keese, Jörg Sturm, Dirk Schadendorf, Stefan Eichmüller |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1741075912 | ||
| 003 | DE-627 | ||
| 005 | 20230428021709.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201125s2004 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.canlet.2003.11.021 |2 doi | |
| 035 | |a (DE-627)1741075912 | ||
| 035 | |a (DE-599)KXP1741075912 | ||
| 035 | |a (OCoLC)1341379605 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Gerhardt, Axel |d 1976- |e VerfasserIn |0 (DE-588)133080536 |0 (DE-627)534474993 |0 (DE-576)266256503 |4 aut | |
| 245 | 1 | 0 | |a Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer |c Axel Gerhardt, Dirk Usener, Michael Keese, Jörg Sturm, Dirk Schadendorf, Stefan Eichmüller |
| 264 | 1 | |c 24 January 2004 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.11.2020 | ||
| 520 | |a The expression of 14 individual and two groups of tumor antigens was characterized for colorectal carcinoma by RT-PCR using 26 colorectal carcinoma specimens, eight cell lines, six samples of patients with inflammatory bowl diseases, and nine specimens from different locations of an individual patient with a metastasized rectal carcinoma. The most frequently detected mRNAs were MAGE-A1 (58%), GAGE-3-7 (54%), and cTAGE-5a (31%). At medium frequencies (12-19%) we found cTAGE-1, MAGE-A2, se57-1, RAGE-4, and GAGE-1,2,8, while other tumor antigens were expressed rarely (<9%). 85% of the samples were positive for at least one of the most frequently expressed antigens. Using a secondary SEREX approach and sera of eight colorectal cancer patients we found reactive antibodies against recombinant cTAGE-1 (2 sera), se57-1 (2), truncated GAGE (1), and MAGE-A1 (1). We conclude that certain cancer-germline genes can be detected in colorectal cancer and might therefore be promising targets for immunotherapy. | ||
| 650 | 4 | |a Cancer-germline genes | |
| 650 | 4 | |a cTAGE | |
| 650 | 4 | |a GAGE | |
| 650 | 4 | |a MAGE | |
| 650 | 4 | |a NY-ESO-1 | |
| 700 | 1 | |a Usener, Dirk |d 1972- |e VerfasserIn |0 (DE-588)124823378 |0 (DE-627)366751735 |0 (DE-576)294520791 |4 aut | |
| 700 | 1 | |a Keese, Michael |d 1971- |e VerfasserIn |0 (DE-588)120713330 |0 (DE-627)704941805 |0 (DE-576)292352778 |4 aut | |
| 700 | 1 | |a Sturm, Jörg |d 1943- |e VerfasserIn |0 (DE-588)1076688918 |0 (DE-627)835258297 |0 (DE-576)445605553 |4 aut | |
| 700 | 1 | |a Schadendorf, Dirk |d 1960- |e VerfasserIn |0 (DE-588)11142576X |0 (DE-627)499566076 |0 (DE-576)289702275 |4 aut | |
| 700 | 1 | |a Eichmüller, Stefan B. |d 1960- |e VerfasserIn |0 (DE-588)1025289226 |0 (DE-627)721986951 |0 (DE-576)37016704X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer letters |d Amsterdam [u.a.] : Elsevier Science, 1975 |g 208(2004), 2, Seite 197-206 |h Online-Ressource |w (DE-627)320434796 |w (DE-600)2004212-7 |w (DE-576)261677926 |x 1872-7980 |7 nnas |a Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer |
| 773 | 1 | 8 | |g volume:208 |g year:2004 |g number:2 |g pages:197-206 |g extent:10 |a Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.canlet.2003.11.021 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0304383503008115 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201125 | ||
| 993 | |a Article | ||
| 994 | |a 2004 | ||
| 998 | |g 1025289226 |a Eichmüller, Stefan B. |m 1025289226:Eichmüller, Stefan B. |d 140000 |e 140000PE1025289226 |k 0/140000/ |p 6 |y j | ||
| 998 | |g 11142576X |a Schadendorf, Dirk |m 11142576X:Schadendorf, Dirk |d 50000 |e 50000PS11142576X |k 0/50000/ |p 5 | ||
| 998 | |g 1076688918 |a Sturm, Jörg |m 1076688918:Sturm, Jörg |d 60000 |d 61800 |e 60000PS1076688918 |e 61800PS1076688918 |k 0/60000/ |k 1/60000/61800/ |p 4 | ||
| 998 | |g 120713330 |a Keese, Michael |m 120713330:Keese, Michael |d 60000 |d 61800 |e 60000PK120713330 |e 61800PK120713330 |k 0/60000/ |k 1/60000/61800/ |p 3 | ||
| 998 | |g 133080536 |a Gerhardt, Axel |m 133080536:Gerhardt, Axel |d 60000 |e 60000PG133080536 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1741075912 |e 3812294729 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1016/j.canlet.2003.11.021"],"eki":["1741075912"]},"relHost":[{"id":{"zdb":["2004212-7"],"eki":["320434796"],"issn":["1872-7980"]},"recId":"320434796","pubHistory":["1.1975 -"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"part":{"volume":"208","extent":"10","pages":"197-206","text":"208(2004), 2, Seite 197-206","year":"2004","issue":"2"},"note":["Gesehen am 22.01.2020"],"origin":[{"publisher":"Elsevier Science","dateIssuedKey":"1975","publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1975-"}],"title":[{"title":"Cancer letters","title_sort":"Cancer letters","subtitle":"an international journal providing a forum for original and pertinent contributions in cancer research"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancerCancer letters"}],"physDesc":[{"extent":"10 S."}],"name":{"displayForm":["Axel Gerhardt, Dirk Usener, Michael Keese, Jörg Sturm, Dirk Schadendorf, Stefan Eichmüller"]},"recId":"1741075912","note":["Gesehen am 25.11.2020"],"title":[{"title":"Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer","title_sort":"Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer"}],"origin":[{"dateIssuedKey":"2004","dateIssuedDisp":"24 January 2004"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"person":[{"family":"Gerhardt","display":"Gerhardt, Axel","role":"aut","given":"Axel"},{"family":"Usener","display":"Usener, Dirk","role":"aut","given":"Dirk"},{"role":"aut","given":"Michael","family":"Keese","display":"Keese, Michael"},{"display":"Sturm, Jörg","family":"Sturm","given":"Jörg","role":"aut"},{"display":"Schadendorf, Dirk","family":"Schadendorf","given":"Dirk","role":"aut"},{"family":"Eichmüller","display":"Eichmüller, Stefan B.","role":"aut","given":"Stefan B."}]} | ||
| SRT | |a GERHARDTAXTISSUEEXPR2420 | ||