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Vascular endothelial growth factor receptor-3 expression predicts sentinel node status in primary cutaneous melanoma

This study analysed the expression of vascular endothelial growth factor-A (VEGF), VEGFR-2, and VEGFR-3 in primary cutaneous melanomas with positive and negative sentinel node status (SLN) (a total of 58 specimens divided into 2 groups of 29 for each status). The specimens were collected from the pa...

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Main Authors: Toberer, Ferdinand (Author) , Hänßle, Holger (Author) , Laimer, Martin (Author) , Heinzel-Gutenbrunner, Monika (Author) , Enk, Alexander (Author) , Hartschuh, Wolfgang (Author) , Helmbold, Peter (Author) , Kutzner, Heinz (Author)
Format: Article (Journal)
Language:English
Published: July 3, 2020
In: Acta dermato-venereologica
Year: 2020, Volume: 100
ISSN:1651-2057
DOI:10.2340/00015555-3588
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2340/00015555-3588
Verlag, lizenzpflichtig, Volltext: https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-3588
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Author Notes:Ferdinand Toberer, Holger A. Haenssle, Martin Laimer, Monika Heinzel-Gutenbrunner, Alexander Enk, Wolfgang Hartschuh, Peter Helmbold and Heinz Kutzner
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Summary:This study analysed the expression of vascular endothelial growth factor-A (VEGF), VEGFR-2, and VEGFR-3 in primary cutaneous melanomas with positive and negative sentinel node status (SLN) (a total of 58 specimens divided into 2 groups of 29 for each status). The specimens were collected from the pathological archive of the department of Dermatology, Venereology and Allergology of the University Medical Center Heidelberg. A quantification score was developed for protein expression, by considering the percentage of positive melanoma cells (0: 0%, 1: up to 1%, 2: 2-10%, 3: 11-50%, and 4: 50%) in relation to the intensity of staining (0: negative, 1: low, 2: medium, 3: strong). Tumoural VEGFR-3 expression (mean +/- standard deviation) in SLN+ tumours (9.62 +/- 3.09) was significantly stronger than in SLN- tumours (6.13 +/- 3.87; p < 0.001). A binary logistic regression model proved VEGFR-3 expression and tumour thickness to be significant independent predictors of SLN. These data provide evidence that VEGFR-3 expression may play a critical role in the pathogenesis of malignant melanoma and that its investigation may help to improve the selection of patients with primary cutaneous melanoma for sentinel node biopsy.
Item Description:Gesehen am 26.11.2020
Physical Description:Online Resource
ISSN:1651-2057
DOI:10.2340/00015555-3588

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