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Bioengineering bone tissue with 3D printed scaffolds in the presence of oligostilbenes

Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehi...

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Main Authors: Posa, Francesca (Author) , Di Benedetto, Adriana (Author) , Ravagnan, Giampietro (Author) , Cavalcanti-Adam, Elisabetta A. (Author) , Lo Muzio, Lorenzo (Author) , Percoco, Gianluca (Author) , Mori, Giorgio (Author)
Format: Article (Journal)
Language:English
Published: 9 October 2020
In: Materials
Year: 2020, Volume: 13, Issue: 20
ISSN:1996-1944
DOI:10.3390/ma13204471
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ma13204471
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1996-1944/13/20/4471
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Author Notes:Francesca Posa, Adriana Di Benedetto, Giampietro Ravagnan, Elisabetta Ada Cavalcanti-Adam, Lorenzo Lo Muzio, Gianluca Percoco and Giorgio Mori
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Summary:Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehiscence have been obtained using adult mesenchymal stem cells (MSCs) integrated with biocompatible scaffolds. The geometry of the scaffold has critical effects on cell adhesion, proliferation and differentiation. Many cytokines and compounds have been demonstrated to be effective in promoting MSCs osteogenic differentiation. Oligostilbenes, such as Resveratrol (Res) and Polydatin (Pol), can increase MSCs osteoblastic features. 3D printing is an excellent technique to create scaffolds customized for the lesion and thus optimized for the patient. In this work we analyze osteoblastic features of adult MSCs integrated with 3D-printed polycarbonate scaffolds differentiated in the presence of oligostilbenes.
Item Description:Gesehen am 26.11.2020
Physical Description:Online Resource
ISSN:1996-1944
DOI:10.3390/ma13204471

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