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Radiosensitization by histone deacetylase inhibition in an osteosarcoma mouse model

Osteosarcomas (OS) are highly malignant and radioresistant tumors. Histone deacetylase inhibitors (HDACi) constitute a novel class of anticancer agents. We sought to investigate the effect of combined treatment with suberoylanilide hydroxamic acid (SAHA) and radiotherapy in OS in vivo.

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Bibliographic Details
Main Authors: Blattmann, Claudia (Author) , Thiemann, Markus (Author) , Stenzinger, Albrecht (Author) , Christmann, A. (Author) , Roth, Eva (Author) , Ehemann, Volker (Author) , Debus, Jürgen (Author) , Kulozik, Andreas (Author) , Weichert, Wilko (Author) , Huber, Peter E. (Author) , Oertel, Susanne (Author) , Abdollahi, Amir (Author)
Format: Article (Journal)
Language:English
Published: 23 June 2013
In: Strahlentherapie und Onkologie
Year: 2013, Volume: 189, Issue: 11, Pages: 957-966
ISSN:1439-099X
DOI:10.1007/s00066-013-0372-8
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00066-013-0372-8
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Author Notes:C. Blattmann, M. Thiemann, A. Stenzinger, A. Christmann, E. Roth, V. Ehemann, J. Debus, A.E. Kulozik, W. Weichert, P.E. Huber, S. Oertel, A. Abdollahi
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Summary:Osteosarcomas (OS) are highly malignant and radioresistant tumors. Histone deacetylase inhibitors (HDACi) constitute a novel class of anticancer agents. We sought to investigate the effect of combined treatment with suberoylanilide hydroxamic acid (SAHA) and radiotherapy in OS in vivo.
Item Description:Gesehen am 26.11.2020
Physical Description:Online Resource
ISSN:1439-099X
DOI:10.1007/s00066-013-0372-8

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