An insulin-sensitive circular RNA that regulates lifespan in drosophila
Circular RNAs (circRNAs) are abundant and accumulate with age in neurons of diverse species. However, only few circRNAs have been functionally characterized, and their role during aging has not been addressed. Here, we use transcriptome profiling during aging and find that accumulation of circRNAs i...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
Jul 16 2020
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| In: |
Molecular cell
Year: 2020, Volume: 79, Issue: 2, Pages: 268-279 |
| ISSN: | 1097-4164 |
| DOI: | 10.1016/j.molcel.2020.06.011 |
| Online Access: | Resolving-System, Volltext: https://doi.org/10.1016/j.molcel.2020.06.011
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| Author Notes: | Carina Marianne Weigelt, Rohan Sehgal, Luke Stephen Tain, Jun Cheng, Jacqueline Esser, Andre Pahl, Christoph Dieterich, Sebastian Groenke, Linda Partridge |
| Summary: | Circular RNAs (circRNAs) are abundant and accumulate with age in neurons of diverse species. However, only few circRNAs have been functionally characterized, and their role during aging has not been addressed. Here, we use transcriptome profiling during aging and find that accumulation of circRNAs is slowed down in long-lived insulin mutant flies. Next, we characterize the in vivo function of a circRNA generated by the sulfateless gene (circSfl), which is consistently upregulated, particularly in the brain and muscle, of diverse long-lived insulin mutants. Strikingly, lifespan extension of insulin mutants is dependent on circSfl, and overexpression of circSfl alone is sufficient to extend the lifespan. Moreover, circSfl is translated into a protein that shares the N terminus and potentially some functions with the full-length Sfl protein encoded by the host gene. Our study demonstrates that insulin signaling affects global circRNA accumulation and reveals an important role of circSfl during aging in vivo. |
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| Item Description: | Gesehen am 26.11.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1097-4164 |
| DOI: | 10.1016/j.molcel.2020.06.011 |