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Short, terminally modified 2′-OMe RNAs as inhibitors of microRNA

We applied 14-mer 2′-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5′-terminus and three 2′-fluoro-2′-deoxynucleotides at the 3′-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better...

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Bibliographic Details
Main Authors: Blechinger, Jenny (Author) , Pieper, Hanna (Author) , Marzenell, Paul (Author) , Kovbasyuk, Larisa (Author) , Serva, Andrius (Author) , Starkuviene-Erfle, Vytaute (Author) , Erfle, Holger (Author) , Mokhir, Andriy (Author)
Format: Article (Journal)
Language:English
Published: 28 June 2013
In: Chemical communications
Year: 2013, Volume: 49, Issue: 67, Pages: 7397-7399
ISSN:1364-548X
DOI:10.1039/C3CC43174F
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C3CC43174F
Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2013/cc/c3cc43174f
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Author Notes:Jenny Blechinger, Hanna Pieper, Paul Marzenell, Larisa Kovbasyuk, Andrius Serva, Vytaute Starkuviene, Holger Erfle and Andriy Mokhir
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Summary:We applied 14-mer 2′-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5′-terminus and three 2′-fluoro-2′-deoxynucleotides at the 3′-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.
Item Description:Gesehen am 27.11.2020
Physical Description:Online Resource
ISSN:1364-548X
DOI:10.1039/C3CC43174F

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