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HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A

HIV-1 Vpu induces downregulation of cell surface NTB-A to evade lysis of HIV-1 infected cells by NK cells. Here we show that Vpu affects the anterograde transport and the glycosylation pattern of NTB-A by a mechanism that is distinct from the Vpu induced downregulation of CD4 and tetherin. In the pr...

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Main Authors: Bolduan, Sebastian (Author) , Hubel, Philipp (Author) , Reif, Tatjana (Author) , Lodermeyer, Veronika (Author) , Höhne, Kristin (Author) , Fritz, Joëlle (Author) , Sauter, Daniel (Author) , Kirchhoff, Frank (Author) , Fackler, Oliver Till (Author) , Schindler, Michael (Author) , Schubert, Ulrich (Author)
Format: Article (Journal)
Language:English
Published: 22 March 2013
In: Virology
Year: 2013, Volume: 440, Issue: 2, Pages: 190-203
ISSN:1096-0341
DOI:10.1016/j.virol.2013.02.021
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.virol.2013.02.021
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0042682213001268
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Author Notes:Sebastian Bolduan, Philipp Hubel, Tatjana Reif, Veronika Lodermeyer, Kristin Höhne, Joëlle V. Fritz, Daniel Sauter, Frank Kirchhoff, Oliver T. Fackler, Michael Schindler, Ulrich Schubert
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Summary:HIV-1 Vpu induces downregulation of cell surface NTB-A to evade lysis of HIV-1 infected cells by NK cells. Here we show that Vpu affects the anterograde transport and the glycosylation pattern of NTB-A by a mechanism that is distinct from the Vpu induced downregulation of CD4 and tetherin. In the presence of Vpu, only the high mannose form of NTB-A was detectable, suggesting that Vpu prevented the formation of the mature form of NTB-A. This phenomenon is associated with the ability of Vpu to downregulate cell surface NTB-A by retention of NTB-A within the Golgi-compartment. Furthermore, the Vpu-mediated effect on NTB-A glycosylation is highly conserved among Vpu proteins derived from HIV-1 and SIV and corresponds to the level of downregulation of NTB-A. Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules.
Item Description:Gesehen am 01.12.2020
Physical Description:Online Resource
ISSN:1096-0341
DOI:10.1016/j.virol.2013.02.021

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