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Secretome analysis of cardiomyocytes identifies PCSK6 (proprotein convertase subtilisin/kexin type 6) as a novel player in cardiac remodeling after myocardial infarction

Acute occlusion of a coronary artery results in swift tissue necrosis. Bordering areas of the infarcted myocardium can also experience impaired blood supply and reduced oxygen delivery, leading to altered metabolic and mechanical processes. Although transcriptional changes in hypoxic cardiomyocytes...

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Main Authors: Kuhn, Tim Christian (Author) , Knobel, Johannes (Author) , Burkert-Rettenmaier, Sonja (Author) , Li, Xue (Author) , Meyer, Sören (Author) , Jungmann, Andreas (Author) , Sicklinger, Florian (Author) , Backs, Johannes (Author) , Lasitschka, Felix (Author) , Müller, Oliver J. (Author) , Katus, Hugo (Author) , Krijgsveld, Jeroen (Author) , Leuschner, Florian (Author)
Format: Article (Journal)
Language:English
Published: 26 Feb 2020
In: Circulation
Year: 2020, Volume: 141, Issue: 20, Pages: 1628-1644
ISSN:1524-4539
DOI:10.1161/CIRCULATIONAHA.119.044914
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1161/CIRCULATIONAHA.119.044914
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.044914
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Author Notes:Tim Christian Kuhn, Johannes Knobel, Sonja Burkert-Rettenmaier, Xue Li, Ingmar Sören Meyer, Andreas Jungmann, Florian Sicklinger, Johannes Backs, Felix Lasitschka, Oliver J. Müller, Hugo A. Katus, Jeroen Krijgsveld, Florian Leuschner
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Summary:Acute occlusion of a coronary artery results in swift tissue necrosis. Bordering areas of the infarcted myocardium can also experience impaired blood supply and reduced oxygen delivery, leading to altered metabolic and mechanical processes. Although transcriptional changes in hypoxic cardiomyocytes are well studied, little is known about the proteins that are actively secreted from these cells.
Item Description:Gesehen am 04.12.2020
Physical Description:Online Resource
ISSN:1524-4539
DOI:10.1161/CIRCULATIONAHA.119.044914

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