Buchumschlag

Secretome analysis of cardiomyocytes identifies PCSK6 (proprotein convertase subtilisin/kexin type 6) as a novel player in cardiac remodeling after myocardial infarction

Acute occlusion of a coronary artery results in swift tissue necrosis. Bordering areas of the infarcted myocardium can also experience impaired blood supply and reduced oxygen delivery, leading to altered metabolic and mechanical processes. Although transcriptional changes in hypoxic cardiomyocytes...

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Hauptverfasser: Kuhn, Tim Christian (VerfasserIn) , Knobel, Johannes (VerfasserIn) , Burkert-Rettenmaier, Sonja (VerfasserIn) , Li, Xue (VerfasserIn) , Meyer, Sören (VerfasserIn) , Jungmann, Andreas (VerfasserIn) , Sicklinger, Florian (VerfasserIn) , Backs, Johannes (VerfasserIn) , Lasitschka, Felix (VerfasserIn) , Müller, Oliver J. (VerfasserIn) , Katus, Hugo (VerfasserIn) , Krijgsveld, Jeroen (VerfasserIn) , Leuschner, Florian (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 26 Feb 2020
In: Circulation
Year: 2020, Jahrgang: 141, Heft: 20, Pages: 1628-1644
ISSN:1524-4539
DOI:10.1161/CIRCULATIONAHA.119.044914
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1161/CIRCULATIONAHA.119.044914
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.044914
Volltext
Verfasserangaben:Tim Christian Kuhn, Johannes Knobel, Sonja Burkert-Rettenmaier, Xue Li, Ingmar Sören Meyer, Andreas Jungmann, Florian Sicklinger, Johannes Backs, Felix Lasitschka, Oliver J. Müller, Hugo A. Katus, Jeroen Krijgsveld, Florian Leuschner
Beschreibung
Zusammenfassung:Acute occlusion of a coronary artery results in swift tissue necrosis. Bordering areas of the infarcted myocardium can also experience impaired blood supply and reduced oxygen delivery, leading to altered metabolic and mechanical processes. Although transcriptional changes in hypoxic cardiomyocytes are well studied, little is known about the proteins that are actively secreted from these cells.
Beschreibung:Gesehen am 04.12.2020
Beschreibung:Online Resource
ISSN:1524-4539
DOI:10.1161/CIRCULATIONAHA.119.044914

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