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Immunohistological expression of SOX-10 in triple-negative breast cancer: a descriptive analysis of 113 samples

Background: SRY-related HMG-box 10 (SOX-10) is commonly expressed in triple negative breast cancer (TNBC). However, data on the biological significance of SOX-10 expression is limited. Therefore, we investigated immunhistological SOX-10 expression in TNBC and correlated the results with genetic alte...

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Hauptverfasser: Kriegsmann, Katharina (VerfasserIn) , Flechtenmacher, Christa (VerfasserIn) , Heil, Jörg (VerfasserIn) , Mechtersheimer, Gunhild (VerfasserIn) , Sinn, Peter (VerfasserIn) , Kriegsmann, Mark (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 3 September 2020
In: International journal of molecular sciences
Year: 2020, Jahrgang: 21, Heft: 17
ISSN:1422-0067
DOI:10.3390/ijms21176407
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms21176407
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/21/17/6407
Volltext
Verfasserangaben:Katharina Kriegsmann, Christa Flechtenmacher, Jörg Heil, Jörg Kriegsmann, Gunhild Mechtersheimer, Sebastian Aulmann, Wilko Weichert, Hans-Peter Sinn and Mark Kriegsmann
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Zusammenfassung:Background: SRY-related HMG-box 10 (SOX-10) is commonly expressed in triple negative breast cancer (TNBC). However, data on the biological significance of SOX-10 expression is limited. Therefore, we investigated immunhistological SOX-10 expression in TNBC and correlated the results with genetic alterations and clinical data. Methods: A tissue microarray including 113 TNBC cases was stained by SOX-10. Immunohistological data of AR, BCL2, CD117, p53 and Vimentin was available from a previous study. Semiconductor-based panel sequencing data including commonly altered breast cancer genes was also available from a previous investigation. SOX-10 expression was correlated with clinicopathological, immunohistochemical and genetic data. Results: SOX-10 was significantly associated with CD117 and Vimentin, but not with AR expression. An association of SOX-10 with BCL2, EGFR or p53 staining was not observed. SOX-10-positive tumors harbored more often TP53 mutations but less frequent mutations of PIK3CA or alterations of the PIK3K pathway. SOX-10 expression had no prognostic impact either on disease-free, distant disease-free, or overall survival. Conclusions: While there might be a value of SOX-10 as a differential diagnostic marker to identify metastases of TNBC, its biological role remains to be investigated.
Beschreibung:Gesehen am 04.12.2020
Beschreibung:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms21176407

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