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Clinical results of fibroblast activation protein (FAP) specific PET and implications for radiotherapy planning: systematic review

Small molecules targeting fibroblast activation protein (FAP) have emerged as a new group of tracers for positron emission tomography (PET) in 2018. The purpose of this systematic review is therefore to summarize the evidence that has been gathered to date in patients and to discuss its possible imp...

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Main Authors: Windisch, Paul (Author) , Zwahlen, Daniel R. (Author) , Körber, Stefan A. (Author) , Giesel, Frederik L. (Author) , Debus, Jürgen (Author) , Haberkorn, Uwe (Author) , Adeberg, Sebastian (Author)
Format: Article (Journal)
Language:English
Published: 15 September 2020
In: Cancers
Year: 2020, Volume: 12, Issue: 9
ISSN:2072-6694
DOI:10.3390/cancers12092629
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cancers12092629
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6694/12/9/2629
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Author Notes:Paul Windisch, Daniel R. Zwahlen, Stefan A. Koerber, Frederik L. Giesel, Jürgen Debus, Uwe Haberkorn and Sebastian Adeberg
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Summary:Small molecules targeting fibroblast activation protein (FAP) have emerged as a new group of tracers for positron emission tomography (PET) in 2018. The purpose of this systematic review is therefore to summarize the evidence that has been gathered to date in patients and to discuss its possible implications for radiotherapy planning. The MEDLINE database was searched for the use of FAP-specific PET in cancer patients and the records were screened according to PRISMA guidelines. Nineteen studies were included. While dedicated analyses of FAP-specific PET for radiotherapy planning were available for glioblastoma, head and neck cancers, lung cancer, and tumors of the lower gastrointestinal tract, there is still very limited data for several epidemiologically significant cancers. In conclusion, FAP-specific PET represents a promising imaging modality for radiotherapy planning that warrants further research.
Item Description:Gesehen am 07.12.2020
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers12092629

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