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Adipose tissue properties in tumor-bearing breasts

The tissue stroma plays a major role in tumors’ natural history. Important programs for tumor progression such as epithelial-mesenchymal transition are not activated as cell-autonomous processes but under the conditions of cross talk between tumor and stroma. Adipose tissue is a major component of b...

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Main Authors: Miran, Isabelle (Author) , Scherer, Dominique (Author) , Ostyn, Pauline (Author) , Mazouni, Chafika (Author) , Drusch, Françoise (Author) , Bernard, Marine (Author) , Louvet, Emilie (Author) , Adam, Julien (Author) , Mathieu, Marie-Christine (Author) , Haffa, Mariam (Author) , Antignac, Jean-Philippe (Author) , Le Bizec, Bruno (Author) , Vielh, Philippe (Author) , Dessen, Philippe (Author) , Perdry, Hervé (Author) , Delaloge, Suzette (Author) , Feunteun, Jean (Author)
Format: Article (Journal)
Language:English
Published: 21 August 2020
In: Frontiers in oncology
Year: 2020, Volume: 10
ISSN:2234-943X
DOI:10.3389/fonc.2020.01506
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fonc.2020.01506
Verlag, LF, Volltext: https://www.frontiersin.org/articles/10.3389/fonc.2020.01506/full
Verlag, LF, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472783
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Author Notes:Isabelle Miran, Dominique Scherer, Pauline Ostyn, Chafika Mazouni, Françoise Drusch, Marine Bernard, Emilie Louvet, Julien Adam, Marie-Christine Mathieu, Mariam Haffa, Jean-Philippe Antignac, Bruno Le Bizec, Philippe Vielh, Philippe Dessen, Hervé Perdry, Suzette Delaloge, Jean Feunteun
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Summary:The tissue stroma plays a major role in tumors’ natural history. Important programs for tumor progression such as epithelial-mesenchymal transition are not activated as cell-autonomous processes but under the conditions of cross talk between tumor and stroma. Adipose tissue is a major component of breast stroma. This study compares breast adipose tissues in women with breast tumors to those in healthy women with the ultimate aim of defining a signature that could be translated into biomarkers for cancer risk. In tumor-bearing breasts, we sampled adipose tissues adjacent to, or distant from the tumor. Parameters studied included: adipocytes size and density, immune cell infiltration, vascularization, secretome and gene expression. Adipose tissues from tumor-bearing breasts, whether adjacent to or distant from the tumor, do not differ from each other by any of these parameters. By contrast, adipose tissues from tumor-bearing breasts have the capacity to secrete twice as much interleukin 8 (IL-8) than those from tumor-free breasts and differentially express a set of 200 genes of which many belong to inflammation and integrin signaling pathways. These observations show that adipose tissues from tumor-bearing breasts display unique constitutive properties. We propose that these properties contribute to the permissiveness of the breast tissue to tumor growth as a non-cell autonomous process.
Item Description:Gesehen am 07.12.2020
Physical Description:Online Resource
ISSN:2234-943X
DOI:10.3389/fonc.2020.01506

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