Buchumschlag

Adipose tissue properties in tumor-bearing breasts

The tissue stroma plays a major role in tumors’ natural history. Important programs for tumor progression such as epithelial-mesenchymal transition are not activated as cell-autonomous processes but under the conditions of cross talk between tumor and stroma. Adipose tissue is a major component of b...

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Hauptverfasser: Miran, Isabelle (VerfasserIn) , Scherer, Dominique (VerfasserIn) , Ostyn, Pauline (VerfasserIn) , Mazouni, Chafika (VerfasserIn) , Drusch, Françoise (VerfasserIn) , Bernard, Marine (VerfasserIn) , Louvet, Emilie (VerfasserIn) , Adam, Julien (VerfasserIn) , Mathieu, Marie-Christine (VerfasserIn) , Haffa, Mariam (VerfasserIn) , Antignac, Jean-Philippe (VerfasserIn) , Le Bizec, Bruno (VerfasserIn) , Vielh, Philippe (VerfasserIn) , Dessen, Philippe (VerfasserIn) , Perdry, Hervé (VerfasserIn) , Delaloge, Suzette (VerfasserIn) , Feunteun, Jean (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 21 August 2020
In: Frontiers in oncology
Year: 2020, Jahrgang: 10
ISSN:2234-943X
DOI:10.3389/fonc.2020.01506
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fonc.2020.01506
Verlag, LF, Volltext: https://www.frontiersin.org/articles/10.3389/fonc.2020.01506/full
Verlag, LF, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472783
Volltext
Verfasserangaben:Isabelle Miran, Dominique Scherer, Pauline Ostyn, Chafika Mazouni, Françoise Drusch, Marine Bernard, Emilie Louvet, Julien Adam, Marie-Christine Mathieu, Mariam Haffa, Jean-Philippe Antignac, Bruno Le Bizec, Philippe Vielh, Philippe Dessen, Hervé Perdry, Suzette Delaloge, Jean Feunteun
Beschreibung
Zusammenfassung:The tissue stroma plays a major role in tumors’ natural history. Important programs for tumor progression such as epithelial-mesenchymal transition are not activated as cell-autonomous processes but under the conditions of cross talk between tumor and stroma. Adipose tissue is a major component of breast stroma. This study compares breast adipose tissues in women with breast tumors to those in healthy women with the ultimate aim of defining a signature that could be translated into biomarkers for cancer risk. In tumor-bearing breasts, we sampled adipose tissues adjacent to, or distant from the tumor. Parameters studied included: adipocytes size and density, immune cell infiltration, vascularization, secretome and gene expression. Adipose tissues from tumor-bearing breasts, whether adjacent to or distant from the tumor, do not differ from each other by any of these parameters. By contrast, adipose tissues from tumor-bearing breasts have the capacity to secrete twice as much interleukin 8 (IL-8) than those from tumor-free breasts and differentially express a set of 200 genes of which many belong to inflammation and integrin signaling pathways. These observations show that adipose tissues from tumor-bearing breasts display unique constitutive properties. We propose that these properties contribute to the permissiveness of the breast tissue to tumor growth as a non-cell autonomous process.
Beschreibung:Gesehen am 07.12.2020
Beschreibung:Online Resource
ISSN:2234-943X
DOI:10.3389/fonc.2020.01506

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