Cover Image

Super enhancers define regulatory subtypes and cell identity in neuroblastoma

Half of the children diagnosed with neuroblastoma (NB) have high-risk disease, disproportionately contributing to overall childhood cancer-related deaths. In addition to recurrent gene mutations, there is increasing evidence supporting the role of epigenetic deregulation in disease pathogenesis. Yet...

Full description

Saved in:
Bibliographic Details
Main Authors: Gartlgruber, Moritz (Author) , Sharma, Ashwini Kumar (Author) , Quintero, Andrés (Author) , Dreidax, Daniel (Author) , Jansky, Selina (Author) , Park, Young-Gyu (Author) , Kreth, Sina (Author) , Meder, Johanna (Author) , Dončević, Daria (Author) , Saary, Paul (Author) , Toprak, Umut H. (Author) , Ishaque, Naveed (Author) , Afanasyeva, Elena (Author) , Wecht, Elisa (Author) , Koster, Jan (Author) , Versteeg, Rogier (Author) , Grünewald, Thomas G. P. (Author) , Jones, David T. W. (Author) , Pfister, Stefan (Author) , Henrich, Kai-Oliver (Author) , van Nes, Johan (Author) , Herrmann, Carl (Author) , Westermann, Frank (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Nature cancer
Year: 2021, Volume: 2, Issue: 1, Pages: 114-128
ISSN:2662-1347
DOI:10.1038/s43018-020-00145-w
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/s43018-020-00145-w
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s43018-020-00145-w
Get full text
Author Notes:Moritz Gartlgruber, Ashwini Kumar Sharma, Andrés Quintero, Daniel Dreidax, Selina Jansky, Young-Gyu Park, Sina Kreth, Johanna Meder, Daria Doncevic, Paul Saary, Umut H. Toprak, Naveed Ishaque, Elena Afanasyeva, Elisa Wecht, Jan Koster, Rogier Versteeg, Thomas G.P. Grünewald, David T. W. Jones, Stefan M. Pfister, Kai-Oliver Henrich, Johan van Nes, Carl Herrmann, Frank Westermann
Description
Summary:Half of the children diagnosed with neuroblastoma (NB) have high-risk disease, disproportionately contributing to overall childhood cancer-related deaths. In addition to recurrent gene mutations, there is increasing evidence supporting the role of epigenetic deregulation in disease pathogenesis. Yet, comprehensive cis-regulatory network descriptions from NB are lacking. Here, using genome-wide H3K27ac profiles across 60 NBs, covering the different clinical and molecular subtypes, we identified four major super-enhancer-driven epigenetic subtypes and their underlying master regulatory networks.
Item Description:Published: 07 December 2020
Gesehen am 08.12.2020
Physical Description:Online Resource
ISSN:2662-1347
DOI:10.1038/s43018-020-00145-w

Similar Items