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Time to recurrence is a significant predictor of cancer-specific survival after recurrence in patients with recurrent renal cell carcinoma: results from a comprehensive multi-centre database (CORONA/SATURN-Project)

Objectives To assess the prognostic impact of time to recurrence (TTR) on cancer-specific survival (CSS) after recurrence in patients with renal cell carcinoma (RCC) undergoing radical nephrectomy or nephron-sparing surgery. To analyse differences in clinical and histopathological criteria between p...

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Hauptverfasser: Brookman‐May, Sabine D. (VerfasserIn) , May, Matthias (VerfasserIn) , Shariat, Shahrokh F. (VerfasserIn) , Novara, Giacomo (VerfasserIn) , Zigeuner, Richard (VerfasserIn) , Cindolo, Luca (VerfasserIn) , Cobelli, Ottavio De (VerfasserIn) , Nunzio, Cosimo De (VerfasserIn) , Pahernik, Sascha (VerfasserIn) , Wirth, Manfred (VerfasserIn) , Longo, Nicola (VerfasserIn) , Simonato, Alchiede (VerfasserIn) , Serni, Sergio (VerfasserIn) , Siracusano, Salvatore (VerfasserIn) , Volpe, Alessandro (VerfasserIn) , Morgia, Giuseppe (VerfasserIn) , Bertini, Roberto (VerfasserIn) , Dalpiaz, Orietta (VerfasserIn) , Stief, Christian (VerfasserIn) , Ficarra, Vincenzo (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 23 May 2013
In: BJU international
Year: 2013, Jahrgang: 112, Heft: 7, Pages: 909-916
ISSN:1464-410X
DOI:https://doi.org/10.1111/bju.12246
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1111/bju.12246
Verlag, lizenzpflichtig, Volltext: https://bjui-journals.onlinelibrary.wiley.com/doi/abs/10.1111/bju.12246
Volltext
Verfasserangaben:Sabine D. Brookman‐May, Matthias May, Shahrokh F. Shariat, Giacomo Novara, Richard Zigeuner, Luca Cindolo, Ottavio De Cobelli, Cosimo De Nunzio, Sascha Pahernik, Manfred P. Wirth, Nicola Longo, Alchiede Simonato, Sergio Serni, Salvatore Siracusano, Alessandro Volpe, Giuseppe Morgia, Roberto Bertini, Orietta Dalpiaz, Christian Stief, and Vincenzo Ficarra, Members of the CORONA-Project, the SATURN-Project, and the Young Academic Urologists Renal Cancer Group
Beschreibung
Zusammenfassung:Objectives To assess the prognostic impact of time to recurrence (TTR) on cancer-specific survival (CSS) after recurrence in patients with renal cell carcinoma (RCC) undergoing radical nephrectomy or nephron-sparing surgery. To analyse differences in clinical and histopathological criteria between patients with early and late recurrence. Patients and Methods Of 13 107 patients with RCC from an international multicentre database, 1712 patients developed recurrence in the follow-up (FU), at a median (interquartile range) of 50.1 (25-106) months. In all, 1402 patients had recurrence at ≤5 years (Group A) and 310 patients beyond this time (Group B). Differences in clinical and histopathological variables between patients with early and late recurrence were analysed. The influence of TTR and further variables on CSS after recurrence was assessed by Cox regression analysis. Results Male gender, advanced age, tumour diameter and stage, Fuhrman grade 3-4, lymphovascular invasion (LVI), and pN + stage were significantly more frequent in patients with early recurrence, who had a significantly reduced 3-year CSS of 30% compared with patients in Group B (41%; P = 0.001). Age, gender, tumour histology, pT stage, and continuous TTR (hazard ratio 0.99, P = 0.006; monthly interval) independently predicted CSS. By inclusion of dichotomised TTR in the multivariable model, a significant influence of this variable on CSS was present until 48 months after surgery, but not beyond this time. Conclusions Advanced age, male gender, larger tumour diameters, LVI, Fuhrman grade 3-4, pN + stage, and advanced tumour stages are associated with early recurrence. Up to 4 years from surgery, a shorter TTR independently predicts a reduced CSS after recurrence.
Beschreibung:Gesehen am 08.12.2020
Beschreibung:Online Resource
ISSN:1464-410X
DOI:https://doi.org/10.1111/bju.12246

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