Quantification of conversion and degradation of circulating angiotensin in rats

The aim of the present study was to quantify with a uniform technique the rates of conversion of ANG I to ANG II in the lung and kidney and the degradation of both peptides to biologically inactive products in the pulmonary, renal, and systemic circulation. We infused the peptides intravenously, int...

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Main Authors: Bauer, Johannes (Author) , Berthold, Heike (Author) , Schaefer, Franz (Author) , Ehmke, Heimo (Author) , Parekh, Niranjan (Author)
Format: Article (Journal)
Language:English
Published: 1 August 1999
In: American journal of physiology. Regulatory, integrative and comparative physiology
Year: 1999, Volume: 277, Issue: 2, Pages: R412-R418
ISSN:1522-1490
DOI:10.1152/ajpregu.1999.277.2.R412
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1152/ajpregu.1999.277.2.R412
Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/ajpregu.1999.277.2.R412
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Author Notes:Johannes Bauer, Heike Berthold, Franz Schaefer, Heimo Ehmke, and Niranjan Parekh
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Summary:The aim of the present study was to quantify with a uniform technique the rates of conversion of ANG I to ANG II in the lung and kidney and the degradation of both peptides to biologically inactive products in the pulmonary, renal, and systemic circulation. We infused the peptides intravenously, into the left ventricle, and into the left renal artery of rats and compared their effects on renal blood flow.
Item Description:Gesehen am 10.12.2020
Physical Description:Online Resource
ISSN:1522-1490
DOI:10.1152/ajpregu.1999.277.2.R412