Immunogenicity of constitutively active V599EBRaf
Activating BRAF somatic missense mutations within the kinase domain are present in 60-66% of melanomas. The vast majority of these represent a single substitution of glutamate for valine (V599E). Here, we demonstrate spontaneous HLA-B*2705-restricted cytotoxic T-cell responses against an epitope der...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2, 2004
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| In: |
Cancer research
Year: 2004, Volume: 64, Issue: 15, Pages: 5456-5460 |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-04-0937 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/0008-5472.CAN-04-0937 Verlag, lizenzpflichtig, Volltext: https://cancerres.aacrjournals.org/content/64/15/5456 
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| Author Notes: | Mads Hald Andersen, Joachim Fensterle, Selma Ugurel, Sine Reker, Roland Houben, Per Guldberg, Thomas G. Berger, Dirk Schadendorf, Uwe Trefzer, Eva-B. Bröcker, Per thor Straten, Ulf R. Rapp, and Jürgen C. Becker |
| Summary: | Activating BRAF somatic missense mutations within the kinase domain are present in 60-66% of melanomas. The vast majority of these represent a single substitution of glutamate for valine (V599E). Here, we demonstrate spontaneous HLA-B*2705-restricted cytotoxic T-cell responses against an epitope derived from V599EBRaf. These T-cell responses were mutation specific as the corresponding epitope derived from wild-type BRaf was not recognized. The loss of the V599EBRAF genotype during progression from primary to metastatic melanoma in patients with V599EBRaf specific T-cell responses suggests an active immune selection of nonmutated melanoma clones by the tumor-bearing host. |
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| Item Description: | Gesehen am 10.12.2020 Im Titel ist der Ausdruck "V599E" hochgestellt |
| Physical Description: | Online Resource |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-04-0937 |