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T cell activation is determined by the number of presented antigens

Antigen recognition is a key event during T cell activation. Here, we introduce nanopatterned antigen arrays that mimic the antigen presenting cell surface during T cell activation. The assessment of activation related events revealed the requirement of a minimal density of 90-140 stimulating major...

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Bibliographic Details
Main Authors: Deeg, Janosch A. (Author) , Axmann, Markus (Author) , Matić, Jovana (Author) , Liapis, Anastasia (Author) , Depoil, David (Author) , Afrose, Jehan (Author) , Curado, Silvia (Author) , Dustin, Michael L. (Author) , Spatz, Joachim P. (Author)
Format: Article (Journal)
Language:English
Published: October 11, 2013
In: Nano letters
Year: 2013, Volume: 13, Issue: 11, Pages: 5619-5626
ISSN:1530-6992
DOI:10.1021/nl403266t
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/nl403266t
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Author Notes:Janosch Deeg, Markus Axmann, Jovana Matic, Anastasia Liapis, David Depoil, Jehan Afrose, Silvia Curado, Michael L. Dustin, and Joachim P. Spatz
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Summary:Antigen recognition is a key event during T cell activation. Here, we introduce nanopatterned antigen arrays that mimic the antigen presenting cell surface during T cell activation. The assessment of activation related events revealed the requirement of a minimal density of 90-140 stimulating major histocompatibility complex class II proteins (pMHC) molecules per μm2. We demonstrate that these substrates induce T cell responses in a pMHC dose-dependent manner and that the number of presented pMHCs dominates over local pMHC density.
Item Description:Gesehen am 10.12.2020
Physical Description:Online Resource
ISSN:1530-6992
DOI:10.1021/nl403266t

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