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T cell activation is determined by the number of presented antigens

Antigen recognition is a key event during T cell activation. Here, we introduce nanopatterned antigen arrays that mimic the antigen presenting cell surface during T cell activation. The assessment of activation related events revealed the requirement of a minimal density of 90-140 stimulating major...

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Bibliographische Detailangaben
Hauptverfasser: Deeg, Janosch A. (VerfasserIn) , Axmann, Markus (VerfasserIn) , Matić, Jovana (VerfasserIn) , Liapis, Anastasia (VerfasserIn) , Depoil, David (VerfasserIn) , Afrose, Jehan (VerfasserIn) , Curado, Silvia (VerfasserIn) , Dustin, Michael L. (VerfasserIn) , Spatz, Joachim P. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: October 11, 2013
In: Nano letters
Year: 2013, Jahrgang: 13, Heft: 11, Pages: 5619-5626
ISSN:1530-6992
DOI:10.1021/nl403266t
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/nl403266t
Volltext
Verfasserangaben:Janosch Deeg, Markus Axmann, Jovana Matic, Anastasia Liapis, David Depoil, Jehan Afrose, Silvia Curado, Michael L. Dustin, and Joachim P. Spatz
Beschreibung
Zusammenfassung:Antigen recognition is a key event during T cell activation. Here, we introduce nanopatterned antigen arrays that mimic the antigen presenting cell surface during T cell activation. The assessment of activation related events revealed the requirement of a minimal density of 90-140 stimulating major histocompatibility complex class II proteins (pMHC) molecules per μm2. We demonstrate that these substrates induce T cell responses in a pMHC dose-dependent manner and that the number of presented pMHCs dominates over local pMHC density.
Beschreibung:Gesehen am 10.12.2020
Beschreibung:Online Resource
ISSN:1530-6992
DOI:10.1021/nl403266t

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