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Differences in advanced magnetic resonance imaging in MOG-IgG and AQP4-IgG seropositive neuromyelitis optica spectrum disorders: a comparative study

Aims: To explore differences in advanced brain magnetic resonance imaging (MRI) characteristics between myelin oligodendrocyte (MOG) immunoglobulin (IgG) and aquaporin-4 (AQP4) IgG seropositive (+) neuromyelitis optica spectrum disorders (NMOSD). Methods: 33 AQP4-IgG and 18 MOG-IgG seropositive NMOS...

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Main Authors: Schmidt, Felix (Author) , Chien, Claudia (Author) , Kuchling, Joseph (Author) , Bellmann-Strobl, Judith (Author) , Ruprecht, Klemens (Author) , Siebert, Nadja (Author) , Asseyer, Susanna (Author) , Jarius, Sven (Author) , Brandt, Alexander U. (Author) , Scheel, Michael (Author) , Paul, Friedemann (Author)
Format: Article (Journal)
Language:English
Published: 30 September 2020
In: Frontiers in neurology
Year: 2020, Volume: 11
ISSN:1664-2295
DOI:10.3389/fneur.2020.499910
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fneur.2020.499910
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fneur.2020.499910/full
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Author Notes:Felix A. Schmidt, Claudia Chien, Joseph Kuchling, Judith Bellmann-Strobl, Klemens Ruprecht, Nadja Siebert, Susanna Asseyer, Sven Jarius, Alexander U. Brandt, Michael Scheel and Friedemann Paul
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Summary:Aims: To explore differences in advanced brain magnetic resonance imaging (MRI) characteristics between myelin oligodendrocyte (MOG) immunoglobulin (IgG) and aquaporin-4 (AQP4) IgG seropositive (+) neuromyelitis optica spectrum disorders (NMOSD). Methods: 33 AQP4-IgG and 18 MOG-IgG seropositive NMOSD patients and 61 healthy control (HC) subjects were included. All 112 participants were scanned with the same standardized MRI-protocol on a 3-Tesla MRI-scanner. Brain volume and diffusion tensor imaging (DTI) parameters were assessed. Results: MOG-IgG+ patients showed reduced parallel diffusivity within white matter tracts compared to HC whereas AQP4-IgG+ showed no significant brain parenchymal damage in DTI analysis. AQP4-IgG+ patients showed reduced whole brain volumes and reduced volumes of several deep grey matter structures compared to HC whereas MOG-IgG+ patients did not show reduced brain or deep grey matter volumes compared to HC. Conclusions: Microstructural brain parenchymal damage in MOG-IgG+ patients was more pronounced than in AQP4-IgG+ patients, compared with HC, whereas normalized brain volume reduction was more severe in AQP4-IgG+ patients. Longitudinal imaging studies are warranted to further investigate this trend in NMOSD. Our results suggest that MOG-IgG+ and AQP4-IgG+ NMOSD patients differ in cerebral MRI characteristics. Advanced MRI analysis did not help to differentiate between MOG-IgG+ and AQP4-IgG+ patients in our study.
Item Description:Gesehen am 14.12.2020
Physical Description:Online Resource
ISSN:1664-2295
DOI:10.3389/fneur.2020.499910

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