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The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy?

The glycoprotein MFG-E8 mediates phagocytic clearance of apoptotic cells and influences the pathogenesis and progression of inflammatory diseases. MFG-E8 was shown to attenuate the progression of inflammation and to improve survival in septic rats. Accumulating evidence suggests an immunomodulatory...

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Main Authors: D'Haese, Jan Goesta (Author) , Demir, Ihsan Ekin (Author) , Kehl, Timo (Author) , Winckler, Jannik (Author) , Giese, Nathalia (Author) , Bergmann, Frank (Author) , Giese, Thomas (Author) , Büchler, Markus W. (Author) , Friess, Helmut (Author) , Hartel, Mark (Author) , Ceyhan, Güralp Onur (Author)
Format: Article (Journal)
Language:English
Published: 16 January 2013
In: BMC gastroenterology
Year: 2013, Volume: 13
ISSN:1471-230X
DOI:10.1186/1471-230X-13-14
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-230X-13-14
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Author Notes:Jan G. D’Haese, Ihsan Ekin Demir, Timo Kehl, Jannik Winckler, Nathalia A. Giese, Frank Bergmann, Thomas Giese, Markus W. Büchler, Helmut Friess, Mark Hartel and Güralp O. Ceyhan
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Summary:The glycoprotein MFG-E8 mediates phagocytic clearance of apoptotic cells and influences the pathogenesis and progression of inflammatory diseases. MFG-E8 was shown to attenuate the progression of inflammation and to improve survival in septic rats. Accumulating evidence suggests an immunomodulatory link between MFG-E8 and the pro-inflammatory chemokine fractalkine, which may determine the severity of pain, fibrosis, and inflammation in chronic pancreatitis (CP).
Item Description:Gesehen am 14.12.2020
Physical Description:Online Resource
ISSN:1471-230X
DOI:10.1186/1471-230X-13-14

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