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The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy?

The glycoprotein MFG-E8 mediates phagocytic clearance of apoptotic cells and influences the pathogenesis and progression of inflammatory diseases. MFG-E8 was shown to attenuate the progression of inflammation and to improve survival in septic rats. Accumulating evidence suggests an immunomodulatory...

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Detalles Bibliográficos
Autores principales: D'Haese, Jan Goesta (Autor) , Demir, Ihsan Ekin (Autor) , Kehl, Timo (Autor) , Winckler, Jannik (Autor) , Giese, Nathalia (Autor) , Bergmann, Frank (Autor) , Giese, Thomas (Autor) , Büchler, Markus W. (Autor) , Friess, Helmut (Autor) , Hartel, Mark (Autor) , Ceyhan, Güralp Onur (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: 16 January 2013
In: BMC gastroenterology
Year: 2013, Volumen: 13
ISSN:1471-230X
DOI:10.1186/1471-230X-13-14
Acceso en línea:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-230X-13-14
Enlace del recurso
Notas de Autor:Jan G. D’Haese, Ihsan Ekin Demir, Timo Kehl, Jannik Winckler, Nathalia A. Giese, Frank Bergmann, Thomas Giese, Markus W. Büchler, Helmut Friess, Mark Hartel and Güralp O. Ceyhan
Descripción
Sumario:The glycoprotein MFG-E8 mediates phagocytic clearance of apoptotic cells and influences the pathogenesis and progression of inflammatory diseases. MFG-E8 was shown to attenuate the progression of inflammation and to improve survival in septic rats. Accumulating evidence suggests an immunomodulatory link between MFG-E8 and the pro-inflammatory chemokine fractalkine, which may determine the severity of pain, fibrosis, and inflammation in chronic pancreatitis (CP).
Notas:Gesehen am 14.12.2020
Descripción Física:Online Resource
ISSN:1471-230X
DOI:10.1186/1471-230X-13-14

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