Lymphocytic hypophysitis with central diabetes insipidus and consequent panhypopituitarism preceding a multifocal, intracranial germinoma in a prepubertal girl
We report the clinical course of a prepubertal girl with central diabetes insipidus (DI) and consequent panhypopituitarism evolving over a period of 10 years due to lymphocytic hypophysitis and subsequent germinoma. Two years after the diagnosis of central DI was established, MRI revealed a thickene...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 1999
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| In: |
European journal of pediatrics
Year: 1999, Volume: 158, Issue: 4, Pages: 288-292 |
| ISSN: | 1432-1076 |
| DOI: | 10.1007/s004310051074 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s004310051074
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| Author Notes: | M. Bettendorf, M. Fehn, J. Grulich-Henn, B. Selle, K. Darge, D.K. Lüdecke, U.E. Heinrich, W. Saeger |
| Summary: | We report the clinical course of a prepubertal girl with central diabetes insipidus (DI) and consequent panhypopituitarism evolving over a period of 10 years due to lymphocytic hypophysitis and subsequent germinoma. Two years after the diagnosis of central DI was established, MRI revealed a thickened pituitary stalk. Later pituitary enlargement and increasing thickening of the pituitary stalk impinging on the optic chiasm required a trans-sphenoidal biopsy which disclosed active hypophysitis with lymphocytic infiltrates and necrosis. High dose dexamethasone treatment only temporarily halted the disease process. Therefore, stereotactic radiation therapy was performed as a rescue treatment and MRI findings almost reversed. However, the subsequent MRI showed multiple intracranial lesions identified histologically as a germinoma and a standard chemotherapy and radiation was performed. |
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| Item Description: | Gesehen am 15.12.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1432-1076 |
| DOI: | 10.1007/s004310051074 |