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Limbic hyperconnectivity in the vegetative state

Objective: To investigate functional connectivity between the default mode network (DMN) and other networks in disorders of consciousness. - Methods: We analyzed MRI data from 11 patients in a vegetative state and 7 patients in a minimally conscious state along with age- and sex-matched healthy cont...

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Main Authors: Di Perri, Carol (Author) , Bastianello, Stefano (Author) , Bartsch, Andreas J. (Author) , Pistarini, Caterina (Author) , Maggioni, Giorgio (Author) , Magrassi, Lorenzo (Author) , Imberti, Roberto (Author) , Pichiecchio, Anna (Author) , Vitali, Paolo (Author) , Laureys, Steven (Author) , Salle, Francesco Di (Author)
Format: Article (Journal)
Language:English
Published: September 18, 2013
In: Neurology
Year: 2013, Volume: 81, Issue: 16, Pages: 1417-1424
ISSN:1526-632X
DOI:10.1212/WNL.0b013e3182a43b78
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1212/WNL.0b013e3182a43b78
Verlag, lizenzpflichtig, Volltext: https://n.neurology.org/content/81/16/1417
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Author Notes:Carol Di Perri, MD, Stefano Bastianello, MD, Andreas J. Bartsch, MD,PhD, Caterina Pistarini, MD, Giorgio Maggioni, MD, Lorenzo Magrassi, MD, Roberto Imberti, MD, Anna Pichiecchio, MD, Paolo Vitali, MD, Steven Laureys, MD,PhD, Francesco Di Salle, MD
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Summary:Objective: To investigate functional connectivity between the default mode network (DMN) and other networks in disorders of consciousness. - Methods: We analyzed MRI data from 11 patients in a vegetative state and 7 patients in a minimally conscious state along with age- and sex-matched healthy control subjects. MRI data analysis included nonlinear spatial normalization to compensate for disease-related anatomical distortions. We studied brain connectivity data from resting-state MRI temporal series, combining noninferential (independent component analysis) and inferential (seed-based general linear model) methods. - Results: In DMN hypoconnectivity conditions, a patient's DMN functional connectivity shifts and paradoxically increases in limbic structures, including the orbitofrontal cortex, insula, hypothalamus, and the ventral tegmental area. - Conclusions: Concurrently with DMN hypoconnectivity, we report limbic hyperconnectivity in patients in vegetative and minimally conscious states. This hyperconnectivity may reflect the persistent engagement of residual neural activity in self-reinforcing neural loops, which, in turn, could disrupt normal patterns of connectivity.
Item Description:Gesehen am 15.12.2020
Physical Description:Online Resource
ISSN:1526-632X
DOI:10.1212/WNL.0b013e3182a43b78

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