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The impact of total body irradiation on the outcome of patients with follicular lymphoma treated with autologous stem-cell transplantation in the modern era: a retrospective study of the EBMT Lymphoma Working Party

BACKGROUND: The aim of this study was to investigate the impact of the high-dose regimen on the outcome of patients with follicular lymphoma (FL) having had autologous stem-cell transplantation (ASCT) in a recent time period. - PATIENTS: Between 1995 and 2007, 2233 patients with FL had their first A...

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Main Authors: El-Najjar, Inas (Author) , Boumendil, A. (Author) , Luan, J. J. (Author) , Bouabdallah, R. (Author) , Thomson, K. (Author) , Mohty, M. (Author) , Colombat, P. (Author) , Biron, P. (Author) , Tilly, H. (Author) , Pfreundschuh, M. (Author) , Cordonnier, C. (Author) , Sureda, A. (Author) , Cahn, J. Y. (Author) , Vernant, J. P. (Author) , Gribben, J. (Author) , Cook, G. (Author) , Haynes, A. P. (Author) , Ferrant, A. (Author) , Finel, H. (Author) , Montoto, S. (Author) , Dreger, Peter (Author)
Format: Article (Journal)
Language:English
Published: 5 September 2014
In: Annals of oncology
Year: 2014, Volume: 25, Issue: 11, Pages: 2224-2229
ISSN:1569-8041
DOI:10.1093/annonc/mdu440
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/annonc/mdu440
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Author Notes:I. El-Najjar, A. Boumendil, J.J. Luan, R. Bouabdallah, K. Thomson, M. Mohty, P. Colombat, P. Biron, H. Tilly, M. Pfreundschuh, C. Cordonnier, A. Sureda, J.Y. Cahn, J.P. Vernant, J. Gribben, G. Cook, A.P. Haynes, A. Ferrant, H. Finel, S. Montoto, P. Dreger on behalf of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
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Summary:BACKGROUND: The aim of this study was to investigate the impact of the high-dose regimen on the outcome of patients with follicular lymphoma (FL) having had autologous stem-cell transplantation (ASCT) in a recent time period. - PATIENTS: Between 1995 and 2007, 2233 patients with FL had their first ASCT with either a total body irradiation (TBI)-containing regimen or carmustin, etoposide, cytarabine and melphalan (BEAM), of which 47% were autografted in first remission. - RESULTS: After a median observation time of 73 months (interquartile range 30-107), 5- and 10-year non-relapse mortality (NRM) was similar (6% and 10% in both groups). No significant NRM differences became evident after multivariate adjustment for confounders. Secondary malignancies were observed in 9.7% and 7.9% of the patients after TBI and BEAM (P = 0.19), which were treatment-related myelodysplastic syndromes/acute myelogenous leukaemia (t-MDS/AML) in 3.4% and 2.8% (P = 0.57). The median time to t-MDS/AML was around 50 months in both groups. Because of a lower relapse incidence, TBI was associated with better event-free survival reaching statistical significance in the patients transplanted in first remission but not in those transplanted beyond first remission. - CONCLUSIONS: In patients with FL who received TBI-based ASCT after 1995 increased NRM and t-MDS/AML risks did not emerge compared with BEAM while disease control was at least equivalent.
Item Description:Gesehen am 17.12.2020
Physical Description:Online Resource
ISSN:1569-8041
DOI:10.1093/annonc/mdu440

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