IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol

IKZF1 gene deletions have been associated with a poor outcome in pediatric precursor B-cell acute lymphoblastic leukemia. To assess the prognostic relevance of IKZF1 deletions for patients treated on Berlin-Frankfurt-Münster Study Group trial ALL-BFM 2000, we screened 694 diagnostic acute lymphobla...

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Main Authors: Dörge, Petra (Author) , Meissner, Barbara (Author) , Zimmermann, Martin (Author) , Möricke, Anja (Author) , Schrauder, André (Author) , Bouquin, Jean-Pierre (Author) , Schewe, Denis (Author) , Harbott, Jochen (Author) , Teigler-Schlegel, Andrea (Author) , Ratei, Richard (Author) , Ludwig, Wolf-Dieter (Author) , Köhler, Rolf (Author) , Bartram, Claus R. (Author) , Schrappe, Martin (Author) , Stanulla, Martin (Author) , Cario, Gunnar (Author)
Format: Article (Journal)
Language:English
Published: March 2013
In: Haematologica, the hematology journal
Year: 2013, Volume: 98, Issue: 3, Pages: 428-432
ISSN:1592-8721
DOI:10.3324/haematol.2011.056135
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.2011.056135
Verlag, lizenzpflichtig, Volltext: https://haematologica.org/article/view/6596
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Author Notes:Petra Dörge, Barbara Meissner, Martin Zimmermann, Anja Möricke, André Schrauder, Jean-Pierre Bouquin, Denis Schewe, Jochen Harbott, Andrea Teigler-Schlegel, Richard Ratei, Wolf-Dieter Ludwig, Rolf Koehler, Claus R. Bartram, Martin Schrappe, Martin Stanulla, and Gunnar Cario
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Summary:IKZF1 gene deletions have been associated with a poor outcome in pediatric precursor B-cell acute lymphoblastic leukemia. To assess the prognostic relevance of IKZF1 deletions for patients treated on Berlin-Frankfurt-Münster Study Group trial ALL-BFM 2000, we screened 694 diagnostic acute lymphoblastic leukemia samples by Multiplex Ligation-dependent Probe Amplification. Patients whose leukemic cells bore IKZF1 deletions had a lower 5-year event-free survival (0.69±0.05 vs. 0.85±0.01; P
Item Description:Gesehen am 17.12.2020
Physical Description:Online Resource
ISSN:1592-8721
DOI:10.3324/haematol.2011.056135