Cover Image

Long-term survival after adoptive bone marrow T cell therapy of advanced metastasized breast cancer: follow-up analysis of a clinical pilot trial

The bone marrow (BM) of breast cancer patients harbors tumor-reactive memory T cells (TCs) with therapeutic potential. We recently described the immunologic effects of adoptive transfer of ex vivo restimulated tumor-reactive memory TCs from the BM of 12 metastasized breast cancer patients in a clini...

Full description

Saved in:
Bibliographic Details
Main Authors: Domschke, Christoph (Author) , Ge, Yingzi (Author) , Bernhardt, Isa (Author) , Schott, Sarah (Author) , Keim, Sophia (Author) , Jünger, Simone (Author) , Bucur, Mariana (Author) , Mayer, Luisa (Author) , Blumenstein, Maria (Author) , Rom, Joachim (Author) , Heil, Jörg (Author) , Sohn, Christof (Author) , Schneeweiss, Andreas (Author) , Beckhove, Philipp (Author) , Schütz, Florian (Author)
Format: Article (Journal)
Language:English
Published: 18 April 2013
In: Cancer immunology immunotherapy
Year: 2013, Volume: 62, Pages: 1053-1060
ISSN:1432-0851
DOI:10.1007/s00262-013-1414-x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00262-013-1414-x
Get full text
Author Notes:Christoph Domschke, Yingzi Ge, Isa Bernhardt, Sarah Schott, Sophia Keim, Simone Juenger, Mariana Bucur, Luisa Mayer, Maria Blumenstein, Joachim Rom, Joerg Heil, Christof Sohn, Andreas Schneeweiss, Philipp Beckhove, Florian Schuetz
Description
Summary:The bone marrow (BM) of breast cancer patients harbors tumor-reactive memory T cells (TCs) with therapeutic potential. We recently described the immunologic effects of adoptive transfer of ex vivo restimulated tumor-reactive memory TCs from the BM of 12 metastasized breast cancer patients in a clinical phase-I study. In this trial, adoptive T cell transfer resulted in the occurrence of circulating tumor antigen-reactive type-1 TCs. We here describe the long-term clinical outcome and its correlation with tumor-specific cellular immune response in 16 metastasized breast cancer patients, including 12 included in the original study.
Item Description:Gesehen am 18.12.2020
Physical Description:Online Resource
ISSN:1432-0851
DOI:10.1007/s00262-013-1414-x

Similar Items