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Swimming exercise in combination with garlic extract administration as a therapy against doxorubicin-induced hepatic, heart and renal toxicity to rats

Effect of swimming training is considered on doxorubicin-induced toxicity in the liver, heart, and kidney of rats. Histopathological degeneration could partially be prevented in swimming-trained rats pretreated with garlic extract. Exercise combined with garlic extract reduced the malondialdehyde va...

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Main Authors: Farzanegi, Parvin (Author) , Asadi, Mahdieh (Author) , Abdi, Ahmad (Author) , Etemadian, Marjan (Author) , Amani, Maryam (Author) , Amrollah, Vahideh (Author) , Shahri, Fatemeh (Author) , Gholami, Vali (Author) , Abdi, Zahra (Author) , Moradi, Lida (Author) , Ghorbani, Saeed (Author) , Fallah, Zahra (Author) , Wiskemann, Joachim (Author) , Azarbayjani, Mohammad Ali (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Journal of toxicology. Toxin reviews
Year: 2019, Volume: 39, Issue: 4, Pages: 434-443
ISSN:1525-6057
DOI:10.1080/15569543.2018.1559194
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/15569543.2018.1559194
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Author Notes:Parvin Farzanegi, Mahdieh Asadi, Ahmad Abdi, Marjan Etemadian, Maryam Amani, Vahideh Amrollah, Fatemeh Shahri, Vali Gholami, Zahra Abdi, Lida Moradi, Saeed Ghorbani, Zahra Fallah, Joachim Wiskeman & Mohammad Ali Azarbayjani
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Summary:Effect of swimming training is considered on doxorubicin-induced toxicity in the liver, heart, and kidney of rats. Histopathological degeneration could partially be prevented in swimming-trained rats pretreated with garlic extract. Exercise combined with garlic extract reduced the malondialdehyde value and improved the activities of antioxidant enzymes. Doxorubicin treatment enhanced the mean values of blood ALT, AST, and ALP enzymes, as well as hepatic, cardiac, and renal TNF-α and HSP70 (p < .05). Swimming alone or supplemented with garlic extract can protect liver, heart, and kidney against doxorubicin toxicity by increasing antioxidants and reducing oxidative stress and inflammation.
Item Description:Gesehen am 22.12.2020
First published: 09 Jan 2019
Physical Description:Online Resource
ISSN:1525-6057
DOI:10.1080/15569543.2018.1559194

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