Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis: potential role of lipid peroxidation, dietary fat and antioxidants
<section class="abstract"><h2 class="abstractTitle text-title my-1" id="d2156e2">Abstract</h2><p>Molecular pathways to colorectal cancer involve multiple - genetic changes, whereby extensive oxyradical - damage causes mutations in cancerrelated g...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01.06.2005
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| In: |
Biological chemistry
Year: 2002, Jahrgang: 383, Heft: 6, Pages: 915-921 |
| ISSN: | 1437-4315 |
| DOI: | 10.1515/BC.2002.098 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1515/BC.2002.098 Verlag, lizenzpflichtig, Volltext: https://www.degruyterbrill.com/view/journals/bchm/383/6/article-p915.xml 
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| Verfasserangaben: | Helmut Bartsch, Jagadeesan Nair and Robert W. Owen |
| Zusammenfassung: | <section class="abstract"><h2 class="abstractTitle text-title my-1" id="d2156e2">Abstract</h2><p>Molecular pathways to colorectal cancer involve multiple - genetic changes, whereby extensive oxyradical - damage causes mutations in cancerrelated genes - and leads to a cycle of cell death and regeneration. Besides - direct oxidative DNAdamage, reactive oxygen - and nitrogen species can induce etheno ()DNA - adducts mainly via trans-4-hydroxy-2-nonenal, generated - as the major aldehyde by lipid peroxidation (LPO) - of ω-6 PUFAs. Patients with familial adenomatous - polyposis (FAP) develop multiple colorectal adenomas. - In affected tissues increased LPO could be triggered - due to increased arachidonic acid metabolism - as a result of elevated cyclooxygenases. Our studies - demonstrated an increased DNA adduct level in affected - colon epithelia of FAP patients. DNA adducts - are promutagenic and can cause genomic instability - that drives colorectal adenoma to malignancy. We - have further investigated the potential chemopreventive - properties of olive oil and its polyphenolic components. - Mediterranean diet, of which olive oil is a major - fatty acid source, has protective effects against human - breast and colorectal cancers. Olive oil extracts - and the newly identified lignan fractions showed high - antioxidant capacity in vitro. As DNA adducts are - biomarkers for oxidative stress and LPO induced DNA - damage, they can verify the efficacy of newly identified - antioxidants, e.g. from olive oil, as chemopreventive - agents against colon carcinogenesis.</p></section> |
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| Beschreibung: | Gesehen am 12.01.2021 Elektronische Reproduktion der Druck-Ausgabe |
| Beschreibung: | Online Resource |
| ISSN: | 1437-4315 |
| DOI: | 10.1515/BC.2002.098 |