Growth hormone receptor abundance in tibial growth plates of uremic rats: GH/IGF-I treatment
Growth hormone receptor abundance in tibial growth plates of uremic rats: GH/IGF-I treatment. - Background - Children with chronic renal failure (CRF) exhibit growth retardation and a disturbed growth hormone/insulin-like growth factor-I (GH/IGF-I) axis. Treatment of children with CRF with GH or GH/...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
16 December 2015
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| In: |
Kidney international
Year: 2000, Volume: 58, Issue: 1, Pages: 62-70 |
| ISSN: | 1523-1755 |
| DOI: | 10.1046/j.1523-1755.2000.00141.x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1523-1755.2000.00141.x Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0085253815470747 
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| Author Notes: | Stephanie R. Edmondson, Naomi L. Baker, Jun Oh, Gabor Kovacs, George A. Werther, Otto Mehls |
| Summary: | Growth hormone receptor abundance in tibial growth plates of uremic rats: GH/IGF-I treatment. - Background - Children with chronic renal failure (CRF) exhibit growth retardation and a disturbed growth hormone/insulin-like growth factor-I (GH/IGF-I) axis. Treatment of children with CRF with GH or GH/IGF-I can partially restore linear growth. The molecular basis for decreased longitudinal growth is not known but may involve an impaired action of GH. - Methods - We used the growth-retarded uremic rat model to determine the abundance and distribution of GH receptors (GHRs) in the tibial epiphyseal growth plate and the influence of GH, IGF-I, or combined GH/IGF-I treatment. Pair-fed rats were used as the control. - Results - While all treatment regimes increased body length and weight in both rat groups, only GH/IGF-I treatment increased the total growth plate width. This involved an increase in cell number in the hypertrophic zone, which could also be induced by IGF-I alone. Immunohistochemical analysis showed that uremic rats had decreased abundance of GHRs in the proliferative zone, and only GH/IGF-I therapy could overcome this decrease. These data thus suggest that growth retardation in uremic rats is, at least in part, due to a decrease in GHR abundance in chondrocytes of the proliferative zone of the tibial growth plate. This decreased GHR abundance can be overcome by combined GH/IGF-I therapy, thus enhancing generation and proliferation of hypertrophic zone chondrocytes and increasing growth-plate width. - Conclusion - These studies point to a mechanism for the growth retardation seen in children with CRF, and suggest that combined GH/IGF-I treatment may provide more effective therapy for these patients than GH alone. |
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| Item Description: | Available online 16 December 2015 Gesehen am 12.01.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1523-1755 |
| DOI: | 10.1046/j.1523-1755.2000.00141.x |