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Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia

Chronic renal failure (CRF) is associated with resistance to the growth-promoting and anabolic actions of growth hormone (GH). In rats with CRF induced by partial renal ablation, 7 days of GH treatment had a diminished effect on weight gain and hepatic IGF-1 and IGFBP-1 mRNA levels, compared with sh...

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Bibliographische Detailangaben
Hauptverfasser: Schaefer, Franz (VerfasserIn) , Chen, Yu (VerfasserIn) , Tsao, Tanny (VerfasserIn) , Nouri, Pouneh (VerfasserIn) , Rabkin, Ralph (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: August 1, 2001
In: The journal of clinical investigation
Year: 2001, Jahrgang: 108, Heft: 3, Pages: 467-475
ISSN:1558-8238
DOI:10.1172/JCI11895
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1172/JCI11895
Verlag, lizenzpflichtig, Volltext: https://www.jci.org/articles/view/11895
Volltext
Verfasserangaben:Franz Schaefer, Yu Chen, Tanny Tsao, Pouneh Nouri, and Ralph Rabkin
Beschreibung
Zusammenfassung:Chronic renal failure (CRF) is associated with resistance to the growth-promoting and anabolic actions of growth hormone (GH). In rats with CRF induced by partial renal ablation, 7 days of GH treatment had a diminished effect on weight gain and hepatic IGF-1 and IGFBP-1 mRNA levels, compared with sham-operated pair-fed controls.
Beschreibung:Gesehen am 13.01.2021
Beschreibung:Online Resource
ISSN:1558-8238
DOI:10.1172/JCI11895

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