Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia
Chronic renal failure (CRF) is associated with resistance to the growth-promoting and anabolic actions of growth hormone (GH). In rats with CRF induced by partial renal ablation, 7 days of GH treatment had a diminished effect on weight gain and hepatic IGF-1 and IGFBP-1 mRNA levels, compared with sh...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 1, 2001
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| In: |
The journal of clinical investigation
Year: 2001, Volume: 108, Issue: 3, Pages: 467-475 |
| ISSN: | 1558-8238 |
| DOI: | 10.1172/JCI11895 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1172/JCI11895 Verlag, lizenzpflichtig, Volltext: https://www.jci.org/articles/view/11895 
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| Author Notes: | Franz Schaefer, Yu Chen, Tanny Tsao, Pouneh Nouri, and Ralph Rabkin |
| Summary: | Chronic renal failure (CRF) is associated with resistance to the growth-promoting and anabolic actions of growth hormone (GH). In rats with CRF induced by partial renal ablation, 7 days of GH treatment had a diminished effect on weight gain and hepatic IGF-1 and IGFBP-1 mRNA levels, compared with sham-operated pair-fed controls. |
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| Item Description: | Gesehen am 13.01.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1558-8238 |
| DOI: | 10.1172/JCI11895 |