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Chronic uremia attenuates growth hormone-induced signal transduction in skeletal muscle

Malnutrition and muscle wasting are common in chronic renal failure (CRF) and adversely affect morbidity and mortality. Contributing to the muscle wasting is resistance to growth hormone (GH). For testing whether impaired GH signaling is a cause of the skeletal muscle GH resistance and for elucidati...

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Bibliographic Details
Main Authors: Sun, Di Fei (Author) , Zheng, Zhilan (Author) , Tummala, Padmaja (Author) , Oh, Jun (Author) , Schaefer, Franz (Author) , Rabkin, Ralph (Author)
Format: Article (Journal)
Language:English
Published: October 1, 2004
In: Journal of the American Society of Nephrology
Year: 2004, Volume: 15, Issue: 10, Pages: 2630-2636
ISSN:1533-3450
DOI:10.1097/01.ASN.0000139492.36400.6C
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1097/01.ASN.0000139492.36400.6C
Verlag, lizenzpflichtig, Volltext: https://jasn.asnjournals.org/content/15/10/2630
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Author Notes:Di Fei Sun, Zhilan Zheng, Padmaja Tummala, Jun Oh, Franz Schaefer, and Ralph Rabkin
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Summary:Malnutrition and muscle wasting are common in chronic renal failure (CRF) and adversely affect morbidity and mortality. Contributing to the muscle wasting is resistance to growth hormone (GH). For testing whether impaired GH signaling is a cause of the skeletal muscle GH resistance and for elucidating its mechanisms, muscle GH signaling and action were studied in GH-deficient rats with surgically induced CRF and sham-operated pairfed control rats.
Item Description:Gesehen am 15.01.2021
Physical Description:Online Resource
ISSN:1533-3450
DOI:10.1097/01.ASN.0000139492.36400.6C

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