Prevalence of a first-degree relative with colorectal cancer and uptake of screening among persons 40 to 54 years old
Background & Aims - People with a first-degree relative with colorectal cancer (CRC) are recommended to start CRC screening at age 40. However, there is limited information on how many people in different age groups have a known family history of CRC and how many of them have had a colonoscopy....
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2020
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| In: |
Clinical gastroenterology and hepatology
Year: 2020, Volume: 18, Issue: 11, Pages: 2535-2543, e1-e3 |
| ISSN: | 1542-7714 |
| DOI: | 10.1016/j.cgh.2019.11.044 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cgh.2019.11.044 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1542356519313849 
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| Author Notes: | Korbinian Weigl, Kaja Tikk, Michael Hoffmeister, Jochen Hampe, Svitlana Igel, Frank Kolligs, Stefanie J. Klug, Ulrich Mansmann, Oliver Müller, Jutta M. Nagel, Marcus Pichler, Matthias Schwab, Dirk Schweigler, Anna-Magdalena Stephan, Enrico N. De Toni, Hermann Brenner |
| Summary: | Background & Aims - People with a first-degree relative with colorectal cancer (CRC) are recommended to start CRC screening at age 40. However, there is limited information on how many people in different age groups have a known family history of CRC and how many of them have had a colonoscopy. - Methods - We set up a multicenter, cross-sectional, population-based study in Germany to determine what proportions of persons in age groups from 40 to 54 years old have a known family history of CRC. We invited 160,000 persons to participate in an online survey from 2015 through 2016. We investigated what proportions of persons in each age group reported a family history of CRC and what proportions of persons underwent a colonoscopy examination using descriptive statistics and multiple logistic regression models. - Results - Of 28,711 responders to the online questionnaire (8428 were age 40-44 years, 9879 were age 45-49 years, and 10,404 were age 50-54 years), 2705 stated that they had a first-degree relative with CRC (9.4%). The prevalence of a first-degree relative with CRC increased with age: 7.5%, 9.6%, and 10.9% for people 40 to 44 years old, 45 to 49 years old, and 50 to 54 years old, respectively. The prevalence of a first-degree relative who received a diagnosis of CRC at age 70 years or older increased steadily with each age group. Although a greater proportion of people with a family history of CRC had undergone a colonoscopy examination (54.5%) than people without a family history of CRC (25.7%; P < .0001), large proportions of people within this risk group were not in compliance with the guidelines (54.8%, 47.6%, and 38.6% for ages 40-44 y, 45-49 y, and 50-54 y, respectively). - Conclusions - One in 10 persons in Germany age 40 to 54 years old has a first-degree relative with CRC. Guidelines recommend initiation of screening at ages 40 to 45 years for people with a family history, yet at this age many people do not have a family history of CRC yet, and almost half of persons 40 to 54 years old with a family history of CRC have not yet received a screening colonoscopy. |
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| Item Description: | Available online 4 December 2019 Gesehen am 26.10.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1542-7714 |
| DOI: | 10.1016/j.cgh.2019.11.044 |