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Genome‐wide DNA methylation analysis of colorectal adenomas with and without recurrence reveals an association between cytosine‐phosphate‐guanine methylation and histological subtypes

Aberrant methylation of DNA is supposed to be a major and early driver of colonic adenoma development, which may result in colorectal cancer (CRC). Although gene methylation assays are used already for CRC screening, differential epigenetic alterations of recurring and nonrecurring colorectal adenom...

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Main Authors: Fiedler, David (Author) , Hirsch, Daniela (Author) , Hajj, Nady El (Author) , Yang, Howard H. (Author) , Hu, Yue (Author) , Sticht, Carsten (Author) , Nanda, Indrajit (Author) , Belle, Sebastian (Author) , Rueschoff, Josef (Author) , Lee, Maxwell P. (Author) , Ried, Thomas (Author) , Haaf, Thomas (Author) , Gaiser, Timo (Author)
Format: Article (Journal)
Language:English
Published: 23 July 2019
In: Genes, chromosomes & cancer
Year: 2019, Volume: 58, Issue: 11, Pages: 783-797
ISSN:1098-2264
DOI:10.1002/gcc.22787
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/gcc.22787
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/10.1002/gcc.22787
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Author Notes:David Fiedler, Daniela Hirsch, Nady El Hajj, Howard H. Yang, Yue Hu, Carsten Sticht, Indrajit Nanda, Sebastian Belle, Josef Rueschoff, Maxwell P. Lee, Thomas Ried, Thomas Haaf, Timo Gaiser
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Summary:Aberrant methylation of DNA is supposed to be a major and early driver of colonic adenoma development, which may result in colorectal cancer (CRC). Although gene methylation assays are used already for CRC screening, differential epigenetic alterations of recurring and nonrecurring colorectal adenomas have yet not been systematically investigated.
Item Description:Gesehen am 19.01.2021
Physical Description:Online Resource
ISSN:1098-2264
DOI:10.1002/gcc.22787

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