Genome‐wide DNA methylation analysis of colorectal adenomas with and without recurrence reveals an association between cytosine‐phosphate‐guanine methylation and histological subtypes
Aberrant methylation of DNA is supposed to be a major and early driver of colonic adenoma development, which may result in colorectal cancer (CRC). Although gene methylation assays are used already for CRC screening, differential epigenetic alterations of recurring and nonrecurring colorectal adenom...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 July 2019
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| In: |
Genes, chromosomes & cancer
Year: 2019, Jahrgang: 58, Heft: 11, Pages: 783-797 |
| ISSN: | 1098-2264 |
| DOI: | 10.1002/gcc.22787 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/gcc.22787 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/10.1002/gcc.22787 
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| Verfasserangaben: | David Fiedler, Daniela Hirsch, Nady El Hajj, Howard H. Yang, Yue Hu, Carsten Sticht, Indrajit Nanda, Sebastian Belle, Josef Rueschoff, Maxwell P. Lee, Thomas Ried, Thomas Haaf, Timo Gaiser |
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| 520 | |a Aberrant methylation of DNA is supposed to be a major and early driver of colonic adenoma development, which may result in colorectal cancer (CRC). Although gene methylation assays are used already for CRC screening, differential epigenetic alterations of recurring and nonrecurring colorectal adenomas have yet not been systematically investigated. | ||
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