LOTUS-domain proteins: developmental effectors from a molecular perspective
<section class="abstract"><h2 class="abstractTitle text-title my-1" id="d22e2">Abstract</h2><p>The LOTUS domain (also known as OST-HTH) is a highly conserved protein domain found in a variety of bacteria and eukaryotes. In animals, the LOTUS doma...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 4, 2020
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| In: |
Biological chemistry
Year: 2020, Volume: 402, Issue: 1, Pages: 7-23 |
| ISSN: | 1437-4315 |
| DOI: | 10.1515/hsz-2020-0270 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1515/hsz-2020-0270 Verlag, lizenzpflichtig, Volltext: https://www.degruyterbrill.com/view/journals/bchm/402/1/article-p7.xml 
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| Author Notes: | Jana Kubíková, Rebecca Reinig, Harpreet Kaur Salgania and Mandy Jeske |
| Summary: | <section class="abstract"><h2 class="abstractTitle text-title my-1" id="d22e2">Abstract</h2><p>The LOTUS domain (also known as OST-HTH) is a highly conserved protein domain found in a variety of bacteria and eukaryotes. In animals, the LOTUS domain is present in the proteins Oskar, TDRD5/Tejas, TDRD7/TRAP/Tapas, and MARF1/Limkain B1, all of which play essential roles in animal development, in particular during oogenesis and/or spermatogenesis. This review summarizes the diverse biological as well as molecular functions of LOTUS-domain proteins and discusses their roles as helicase effectors, post-transcriptional regulators, and critical cofactors of piRNA-mediated transcript silencing.</p></section> |
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| Item Description: | Gesehen am 25.01.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1437-4315 |
| DOI: | 10.1515/hsz-2020-0270 |