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D2 dopamine receptor up-regulation, treatment response, neurological soft signs, and extrapyramidal side effects in schizophrenia: a follow-up study with 123I-Iodobenzamide single photon emission computed tomography in the drug-naive state and after neuroleptic treatment

Background: Animal and postmortem studies indicate that neuroleptic therapy may induce D2 dopamine receptor up-regulation in the basal ganglia. Methods: To address this phenomenon in a clinical study, we investigated the D2 dopamine receptor binding in 15 DSM-III-R schizophrenics in the drug-naive s...

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Main Authors: Schröder, Johannes (Author) , Fauth Silvestri, Simone (Author) , Bubeck, Bernd (Author) , Karr, Markus (Author) , Demisch, Sibylle (Author) , Scherrer, Sabine (Author) , Geider, Franz Josef (Author) , Sauer, Heinrich (Author)
Format: Article (Journal)
Language:English
Published: 20 July 1998
In: Biological psychiatry
Year: 1998, Volume: 43, Issue: 9, Pages: 660-665
ISSN:1873-2402
DOI:10.1016/S0006-3223(97)00442-3
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0006-3223(97)00442-3
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0006322397004423
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Author Notes:Johannes Schröder, Simone Silvestri, Bernd Bubeck, Markus Karr, Sibylle Demisch, Sabine Scherrer, Franz J Geider, Heinrich Sauer
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Summary:Background: Animal and postmortem studies indicate that neuroleptic therapy may induce D2 dopamine receptor up-regulation in the basal ganglia. Methods: To address this phenomenon in a clinical study, we investigated the D2 dopamine receptor binding in 15 DSM-III-R schizophrenics in the drug-naive state and 3 days after completion of a standardized neuroleptic therapy (benperidol 12-16 mg/day, for 25 days) using single photon emission computed tomography (SPECT). SPECT scans were obtained 2 hours after intravenous injection of 185 MBq 123I-iodobenzamide. For analysis, basal ganglia to frontal cortex (BG/FC) ratios were calculated and the patient sample was subgrouped into patients with a favorable versus a poor treatment response. Results: Neuroleptic treatment led to decreased BG/FC ratios in patients with a favorable response, but increased ratios in the poor responders (df = 1, F = 4.1, p = .06). Changes of BG/FC ratios were significantly correlated with extrapyramidal side effects but not with neurological soft signs. Conclusions: Our findings suggest that neuroleptic therapy may induce D2 dopamine receptor up-regulation in a subgroup of patients characterized by poor treatment response and pronounced extrapyramidal side effects.
Item Description:Gesehen am 26.01.2021
Physical Description:Online Resource
ISSN:1873-2402
DOI:10.1016/S0006-3223(97)00442-3

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