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Serum anticholinergic activity and cerebral cholinergic dysfunction: an EEG study in frail elderly with and without delirium

Delirium increases morbidity, mortality and healthcare costs especially in the elderly. Serum anticholinergic activity (SAA) is a suggested biomarker for anticholinergic burden and delirium risk, but the association with cerebral cholinergic function remains unclear. To clarify this relationship, we...

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Main Authors: Thomas, Christine (Author) , Hestermann, Ute Marion (Author) , Kopitz, Jürgen (Author) , Plaschke, Konstanze (Author) , Oster, Peter (Author) , Driessen, Martin (Author) , Mundt, Christoph (Author) , Weisbrod, Matthias (Author)
Format: Article (Journal)
Language:English
Published: 15 September 2008
In: BMC neuroscience
Year: 2008, Volume: 9, Pages: 1-10
ISSN:1471-2202
DOI:10.1186/1471-2202-9-86
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2202-9-86
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Author Notes:Christine Thomas, Ute Hestermann, Juergen Kopitz, Konstanze Plaschke, Peter Oster, Martin Driessen, Christoph Mundt, Matthias Weisbrod
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Summary:Delirium increases morbidity, mortality and healthcare costs especially in the elderly. Serum anticholinergic activity (SAA) is a suggested biomarker for anticholinergic burden and delirium risk, but the association with cerebral cholinergic function remains unclear. To clarify this relationship, we prospectively assessed the correlation of SAA with quantitative electroencephalography (qEEG) power, delirium occurrence, functional and cognitive measures in a cross-sectional sample of acutely hospitalized elderly (> 80 y) with high dementia and delirium prevalence.
Item Description:Gesehen am 26.01.2008
Physical Description:Online Resource
ISSN:1471-2202
DOI:10.1186/1471-2202-9-86

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