Squamous cell carcinoma of the mandible - Patterns of metastasis and disease recurrence in dependence of localization and therapy
Introduction - Oral squamous cell carcinomas exhibit distinct patterns of disease progression, depending on their localisation. This study aimed to evaluate clinicopathological data in patients with tumors of the mandibular alveolar process, to facilitate risk assessment and therapy planning. - Mate...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 November 2020
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| In: |
Journal of cranio-maxillofacial surgery
Year: 2020, Volume: 48, Issue: 12, Pages: 1158-1163 |
| ISSN: | 1878-4119 |
| DOI: | 10.1016/j.jcms.2020.10.006 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jcms.2020.10.006 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1010518220302341 
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| Author Notes: | Julius Moratin, Dominik Horn, Karl Metzger, Oliver Ristow, Christa Flechtenmacher, Michael Engel, Jürgen Hoffmann, Kolja Freier, Christian Freudlsperger |
| Summary: | Introduction - Oral squamous cell carcinomas exhibit distinct patterns of disease progression, depending on their localisation. This study aimed to evaluate clinicopathological data in patients with tumors of the mandibular alveolar process, to facilitate risk assessment and therapy planning. - Materials and methods - A retrospective cohort study was designed including patients with squamous cell carcinoma of the mandibular gingiva. Clinical and pathological data were collected to determine the rate of cervical metastases and clinical outcomes depending on tumor stage, localization (anterior, intermediate and posterior) and the extent of tumor resection. - Results - 120 patients were included in the analysis. Rate of metastases was 42.6%. Tumors of the anterior part of the mandible exhibited significantly higher rates of bilateral metastases (anterior: 85.7%, intermediate: 15.8%, posterior: 4%, p < 0.001) and local recurrence (anterior: 25%, intermediate: 16.3%, posterior: 5.5%, p = 0.03) compared to posterior malignancies. - Conclusion - Tumors of the anterior segment of the mandible are characterized by high rates of metastases and local recurrence. Therefore, we propose radical segmental resection and bilateral neck dissection in those patients. |
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| Item Description: | Gesehen am 26.01.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1878-4119 |
| DOI: | 10.1016/j.jcms.2020.10.006 |