Structural insights into DNA loop extrusion by SMC protein complexes
Structural Maintenance of Chromosomes (SMC) protein complexes play key roles in the three-dimensional organization of genomes in all kingdoms of life. Recent insights from chromosome contact mapping experiments and single-molecule imaging assays suggest that these complexes achieve distinct cellular...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13th July 2020
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| In: |
Current opinion in structural biology
Year: 2020, Volume: 65, Pages: 102-109 |
| DOI: | 10.1016/j.sbi.2020.06.009 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.sbi.2020.06.009 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0959440X2030107X 
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| Author Notes: | Sumanjit Datta, Léa Lecomte and Christian H Haering |
| Summary: | Structural Maintenance of Chromosomes (SMC) protein complexes play key roles in the three-dimensional organization of genomes in all kingdoms of life. Recent insights from chromosome contact mapping experiments and single-molecule imaging assays suggest that these complexes achieve distinct cellular functions by extruding large loops of DNA while they move along the chromatin fiber. In this short review, we summarize recent insights into the molecular architecture of these unconventional DNA motor complexes, their interaction with their DNA substrates, and the remarkable dynamic changes they can undergo during their ATPase reaction cycle. |
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| Item Description: | Gesehen am 01.02.2021 |
| Physical Description: | Online Resource |
| DOI: | 10.1016/j.sbi.2020.06.009 |