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Ras gene mutations in vinyl chloride‐induced liver tumours are carcinogen‐specific but vary with cell type and species

Previous studies have shown that a high proportion (5/6) of human liver angiosarcomas (ASL) associated with exposure to vinyl chloride (VC) contains a GC→AT mutation at the Ki‐ras codon 13. This mutation, however, has not been found in 5 ASL or 2 hepatocellular carcinomas (HCC) induced in rats by VC...

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Bibliographic Details
Main Authors: Boivin-Angèle, Sandra (Author) , Wegener, Kurt (Author) , Bartsch, Helmut (Author)
Format: Article (Journal)
Language:English
Published: 07 January 2000
In: International journal of cancer
Year: 2000, Volume: 85, Issue: 2, Pages: 223-227
ISSN:1097-0215
DOI:10.1002/(SICI)1097-0215(20000115)85:2<223::AID-IJC12>3.0.CO;2-H
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/(SICI)1097-0215(20000115)85:2<223::AID-IJC12>3.0.CO;2-H
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-0215(20000115)85:2<223::AID-IJC12>3.0.CO;2-H
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Author Notes:Sandra Boivin‐Angèle, Lydie Lefrançois, Olivier Froment, Andreas Spiethoff, Matthew S. Bogdanffy, Kurt Wegener, Horst Wesch, Alain Barbin, Brigitte Bancel, Christian Trépo, Helmut Bartsch, James Swenberg and Marie-Jeanne Marion
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Summary:Previous studies have shown that a high proportion (5/6) of human liver angiosarcomas (ASL) associated with exposure to vinyl chloride (VC) contains a GC→AT mutation at the Ki‐ras codon 13. This mutation, however, has not been found in 5 ASL or 2 hepatocellular carcinomas (HCC) induced in rats by VC.
Item Description:Gesehen am 02.02.2021
Physical Description:Online Resource
ISSN:1097-0215
DOI:10.1002/(SICI)1097-0215(20000115)85:2<223::AID-IJC12>3.0.CO;2-H

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