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In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids

Bifunctional lipid technology: Cells convert externally added photoactivatable and “clickable” fatty acids into a variety of bifunctional phospholipids that can be covalently linked to their protein-binding partners by irradiation with UV light. Derivatization of the clickable group with a reporter...

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Bibliographische Detailangaben
Hauptverfasser: Haberkant, Per (VerfasserIn) , Sachsenheimer, Timo (VerfasserIn) , Brügger, Britta (VerfasserIn) , Gavin, Anne-Claude (VerfasserIn) , Schultz, Carsten (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 28 February 2013
In: Angewandte Chemie. International edition
Year: 2013, Jahrgang: 52, Heft: 14, Pages: 4033-4038
ISSN:1521-3773
DOI:https://doi.org/10.1002/anie.201210178
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1002/anie.201210178
Verlag, lizenzpflichtig, Volltext: https://www.onlinelibrary.wiley.com/doi/abs/10.1002/anie.201210178
Volltext
Verfasserangaben:Per Haberkant, Reinout Raijmakers, Marjolein Wildwater, Timo Sachsenheimer, Britta Brügger, Kenji Maeda, Martin Houweling, Anne-Claude Gavin, Carsten Schultz, Gerrit van Meer, Albert J.R. Heck, and Joost C.M. Holthuis
Beschreibung
Zusammenfassung:Bifunctional lipid technology: Cells convert externally added photoactivatable and “clickable” fatty acids into a variety of bifunctional phospholipids that can be covalently linked to their protein-binding partners by irradiation with UV light. Derivatization of the clickable group with a reporter molecule makes it possible to identify and image the lipid-bound proteins in situ (see scheme).
Beschreibung:Gesehen am 03.02.2021
Beschreibung:Online Resource
ISSN:1521-3773
DOI:https://doi.org/10.1002/anie.201210178

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