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Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma: feasibility and clinical response

Photon-based radiation therapy does currently not play a major role as local ablative treatment for hepatocellular carcinoma (HCC). Carbon ions offer distinct physical and biological advantages. Due to their inverted dose profile and the high local dose deposition within the Bragg peak, precise dose...

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Main Authors: Habermehl, Daniel (Author) , Debus, Jürgen (Author) , Ganten, Tom M. (Author) , Ganten, Maria-Katharina (Author) , Bauer, Julia (Author) , Brecht, Ingo (Author) , Brons, Stephan (Author) , Haberer, Thomas (Author) , Härtig, Martin (Author) , Jäkel, Oliver (Author) , Parodi, Katia (Author) , Welzel, Thomas (Author) , Combs, Stephanie (Author)
Format: Article (Journal)
Language:English
Published: 13 March 2013
In: Radiation oncology
Year: 2013, Volume: 8
ISSN:1748-717X
DOI:10.1186/1748-717X-8-59
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1748-717X-8-59
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Author Notes:Daniel Habermehl, Jürgen Debus, Tom Ganten, Maria-Katharina Ganten, Julia Bauer, Ingo C. Brecht, Stephan Brons, Thomas Haberer, Martin Haertig, Oliver Jäkel, Katia Parodi, Thomas Welzel and Stephanie E. Combs
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Summary:Photon-based radiation therapy does currently not play a major role as local ablative treatment for hepatocellular carcinoma (HCC). Carbon ions offer distinct physical and biological advantages. Due to their inverted dose profile and the high local dose deposition within the Bragg peak, precise dose application and sparing of normal tissue is possible. Furthermore, carbon ions have an increased relative biological effectiveness (RBE) compared to photons.
Item Description:Gesehen am 09.02.2021
Physical Description:Online Resource
ISSN:1748-717X
DOI:10.1186/1748-717X-8-59

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