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Monitoring contact sensitization to p-phenylenediamine (PPD) by patch testing with PPD 0.3 % in petrolatum

Background Being a contact allergen of general relevance, p-phenylenediamine (PPD) is patch tested in the baseline series. However, PPD 1% in petrolatum may actively sensitize. Patch testing with PPD at 0.35% pet. proved to be safe, as far as active sensitization is concerned. Objectives To determin...

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Main Authors: Geier, Johannes (Author) , Ballmer-Weber, Barbara K. (Author) , Dickel, Heinrich (Author) , Frosch, Peter J. (Author) , Bircher, Andreas (Author) , Weisshaar, Elke (Author) , Hillen, Uwe (Author)
Format: Article (Journal)
Language:English
Published: 19 June 2013
In: Contact dermatitis
Year: 2013, Volume: 69, Pages: 26-31
ISSN:1600-0536
DOI:https://doi.org/10.1111/cod.12075
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1111/cod.12075
Verlag, lizenzpflichtig, Volltext: https://www.onlinelibrary.wiley.com/doi/abs/10.1111/cod.12075
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Author Notes:Johannes Geier, Barbara K. Ballmer‐Weber, Heinrich Dickel, Peter J. Frosch, Andreas Bircher, Elke Weisshaar and Uwe Hillen
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Summary:Background Being a contact allergen of general relevance, p-phenylenediamine (PPD) is patch tested in the baseline series. However, PPD 1% in petrolatum may actively sensitize. Patch testing with PPD at 0.35% pet. proved to be safe, as far as active sensitization is concerned. Objectives To determine whether PPD 0.3% pet. reliably detects PPD sensitization. Methods Patch testing with PPD 0.3% pet. and 1% pet. synchronously was performed in consecutive patients in a multicentre study within the Information Network of Departments of Dermatology. Results Altogether, 2042 patients were patch tested. PPD 1% pet. yielded 6.0% positive reactions (n = 123), and PPD 0.3% pet. yielded 4.7% (n = 95). The synchronous reproducibility of PPD reactions was similar as known from parallel patch tests with identical PPD concentrations. The diagnostic properties of PPD 0.3% pet. expressed as reaction index and positivity ratio were good. Of the 123 patients reacting to PPD 1% pet., 32 (26%) had no positive reaction to PPD 0.3% pet. In 22 of these 32 patients (69%), no clinical relevance could be found. Conclusions As patch testing with PPD 0.3% pet. is reliable according to our results, we recommend replacing PPD 1% pet. in the baseline series with PPD 0.3% pet.
Item Description:Gesehen am 03.02.2020
Physical Description:Online Resource
ISSN:1600-0536
DOI:https://doi.org/10.1111/cod.12075

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