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Biological subtypes of triple-negative breast cancer are associated with distinct morphological changes and clinical behaviour

Abstract: Triple negative breast cancer (TNBC) is a heterogeneous group of tumours accounting for approximately 10-20% of all breast carcinomas. To identify biologically distinct subgroups of TNBC and to assess their clinical properties we examined a series of 142 consecutive patients all of which h...

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Bibliographic Details
Main Authors: Elsawaf, Zeinab (Author) , Sinn, Peter (Author) , Rom, Joachim (Author) , Lorenzo Bermejo, Justo (Author) , Schneeweiss, Andreas (Author) , Aulmann, Sebastian (Author)
Format: Article (Journal)
Language:English
Published: June 27, 2013
In: The breast
Year: 2013, Volume: 22, Issue: 5, Pages: 986-992
ISSN:1532-3080
DOI:10.1016/j.breast.2013.05.012
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.breast.2013.05.012
Verlag, lizenzpflichtig, Volltext: https://www.thebreastonline.com/article/S0960-9776(13)00115-X/abstract
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Author Notes:Zeinab Elsawaf, Hans-Peter Sinn, Joachim Rom, Justo Lorenzo Bermejo, Andreas Schneeweiss, Sebastian Aulmann
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Summary:Abstract: Triple negative breast cancer (TNBC) is a heterogeneous group of tumours accounting for approximately 10-20% of all breast carcinomas. To identify biologically distinct subgroups of TNBC and to assess their clinical properties we examined a series of 142 consecutive patients all of which had received adjuvant cytotoxic chemotherapy using a comprehensive panel of immunostains. Hierarchical unsupervised cluster analysis based on the expression of 13 markers permitted separation of four distinct groups (basal A, basal B, basoluminal, luminal) with the main distinguishing features being cytokeratin (Ck5/6, Ck14, Ck19), EGFR, p53, p16, and Ki-67 expression. Clusters differed with respect to patient age, modified Bloom and Richardson grading, the presence of tumour necrosis, growth pattern and survival, both in uni- and multivariate analysis. Basal (A or B) tumours showed a substantially better outcome compared with basoluminal and luminal tumours. Our data underline the heterogeneity of TNBC and characterise potentially relevant biological subtypes.</p>
Item Description:Gesehen am 05.02.2021
Physical Description:Online Resource
ISSN:1532-3080
DOI:10.1016/j.breast.2013.05.012

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