Melanoma-reactive T cells in the bone marrow of melanoma patients: association with disease stage and disease duration
Using IFN-γ enzyme-linked immunospot, we investigated reactivity of T cells from bone marrow and peripheral blood to melanoma lysate-pulsed autologous dendritic cells in 40 melanoma patients. Melanoma-reactive T cells were present in the bone marrow of seven patients and in peripheral blood of four...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 15, 2006
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| In: |
Cancer research
Year: 2006, Volume: 66, Issue: 12, Pages: 5997-6001 |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-04-0484 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/0008-5472.CAN-04-0484 Verlag, lizenzpflichtig, Volltext: https://cancerres.aacrjournals.org/content/66/12/5997 
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| Author Notes: | Jan Müller-Berghaus, Katrin Ehlert, Selma Ugurel, Viktor Umansky, Mariana Bucur, Volker Schirrmacher, Philipp Beckhove, and Dirk Schadendorf |
| Summary: | Using IFN-γ enzyme-linked immunospot, we investigated reactivity of T cells from bone marrow and peripheral blood to melanoma lysate-pulsed autologous dendritic cells in 40 melanoma patients. Melanoma-reactive T cells were present in the bone marrow of seven patients and in peripheral blood of four patients. In the bone marrow, melanoma-reactive T cells were present in 6 of 21 stage IV patients and in 1 of 10 stage III patients, whereas none were detected in stage I to II patients (0 of 9). The occurrence of tumor-reactive bone marrow T cells in melanoma patients was associated with advanced disease stage, disease duration and tumor load, and independent of treatment. These findings provide new insights into the generation of T-cell responses in melanoma patients. |
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| Item Description: | Gesehen am 09.02.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-04-0484 |