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Genetic developmental timing revealed by inter-species transplantations in fish

Skip to Next Section - The path from a fertilised egg to an embryo involves the coordinated formation of cell types, tissues and organs. Developmental modules comprise discrete units specified by self-sufficient genetic programs that can interact with each other during embryogenesis. Here, we have t...

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Bibliographic Details
Main Authors: Fuhrmann, Jana (Author) , Buono, Lorena (Author) , Adelmann, Leonie (Author) , Martinez-Morales, Juan Ramón (Author) , Centanin, Lázaro (Author)
Format: Article (Journal)
Language:English
Published: November 23, 2020
In: Development
Year: 2020, Volume: 147, Issue: 22, Pages: 1-47
ISSN:1477-9129
DOI:10.1242/dev.192500
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1242/dev.192500
Verlag, lizenzpflichtig, Volltext: https://dev.biologists.org/content/147/22/dev192500
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Author Notes:Jana Franziska Fuhrmann, Lorena Buono, Leonie Adelmann, Juan Ramón Martinez-Morales, Lazaro Centanin
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Summary:Skip to Next Section - The path from a fertilised egg to an embryo involves the coordinated formation of cell types, tissues and organs. Developmental modules comprise discrete units specified by self-sufficient genetic programs that can interact with each other during embryogenesis. Here, we have taken advantage of the different span of embryonic development between two distantly related teleosts, zebrafish (Danio rerio) and medaka (Oryzias latipes) (3 and 9 days, respectively), to explore modularity principles. We report that inter-species blastula transplantations result in the ectopic formation of a retina formed by donor cells - a module. We show that the time taken for the retina to develop follows a genetic program: an ectopic zebrafish retina in medaka develops with zebrafish dynamics. Heterologous transplantation results in a temporal decoupling between the donor retina and host organism, illustrated by two paradigms that require retina-host interactions: lens recruitment and retino-tectal projections. Our results uncover a new experimental system for addressing temporal decoupling along embryonic development, and highlight the presence of largely autonomous but interconnected developmental modules that orchestrate organogenesis.
Item Description:Gesehen am 09.02.2021
Physical Description:Online Resource
ISSN:1477-9129
DOI:10.1242/dev.192500

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