Crystalloid lysozyme inclusions in Paneth cells of vitamin A-deficient rats
The effect of vitamin A-deficiency on jejunal Paneth cells in rats was investigated. Crystalloid particles were observed in secretion granules of Paneth cells from 6 out of 8 rats with vitamin A-deficiency. The particles were similar to those found in Paneth cells under other experimental conditions...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 1990
|
| In: |
Cell & tissue research
Year: 1990, Volume: 260, Issue: 3, Pages: 625-628 |
| ISSN: | 1432-0878 |
| DOI: | 10.1007/BF00297244 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF00297244
|
| Author Notes: | Martin J. Koch, Hans K. Biesalski, Eckart Stofft, Harald Weiser, Helmut E. Gabbert, Hans-P. Dienes, Burkard Schulz-Dobrick, and Karl H. Bässler |
| Summary: | The effect of vitamin A-deficiency on jejunal Paneth cells in rats was investigated. Crystalloid particles were observed in secretion granules of Paneth cells from 6 out of 8 rats with vitamin A-deficiency. The particles were similar to those found in Paneth cells under other experimental conditions. Using an immuno-electron-microscopic technique we demonstrated a clear lysozyme immunoreactivity of these particles. In 2 vitamin A-deficient rats tubular structures have been detected in addition to the crystalloid particles. Crystalloid particles or tubular structures were not detectable in a control group of 8 vitamin A-supplemented rats. The morphological alterations of Paneth cells may be correlated to an impaired local immunity of the intestine during vitamin A-deficiency. |
|---|---|
| Item Description: | Gesehen am 10.02.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1432-0878 |
| DOI: | 10.1007/BF00297244 |