Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach
Magnetic resonance imaging (MRI) of the brain combined with voxel-based morphometry (VBM) has revealed structural changes of grey and white matter in a range of neurological and psychiatric disorders. However, the cellular basis of volume changes observed with VBM has remained unclear. We devised an...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) Kapitel/Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
February 25, 2019
|
| In: |
bioRxiv beta
|
| DOI: | 10.1101/559765 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1101/559765 Verlag, lizenzpflichtig, Volltext: https://www.biorxiv.org/content/10.1101/559765v1 
|
| Verfasserangaben: | Livia Asan, Claudia Falfan-Melgoza, Wolfgang Weber-Fahr, Carlo Beretta, Thomas Kuner and Johannes Knabbe |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1748097024 | ||
| 003 | DE-627 | ||
| 005 | 20230426072715.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210211s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1101/559765 |2 doi | |
| 035 | |a (DE-627)1748097024 | ||
| 035 | |a (DE-599)KXP1748097024 | ||
| 035 | |a (OCoLC)1341392944 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Asan, Livia |d 1993- |e VerfasserIn |0 (DE-588)1226986676 |0 (DE-627)1748088483 |4 aut | |
| 245 | 1 | 0 | |a Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach |c Livia Asan, Claudia Falfan-Melgoza, Wolfgang Weber-Fahr, Carlo Beretta, Thomas Kuner and Johannes Knabbe |
| 264 | 1 | |c February 25, 2019 | |
| 300 | |a 35 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.02.2021 | ||
| 520 | |a Magnetic resonance imaging (MRI) of the brain combined with voxel-based morphometry (VBM) has revealed structural changes of grey and white matter in a range of neurological and psychiatric disorders. However, the cellular basis of volume changes observed with VBM has remained unclear. We devised an approach to systematically correlate changes in grey matter volume (GMV) with cellular composition. Mice were alternately examined with structural MRI and two-photon <i>in vivo</i> microscopy at three time points, taking advantage of age-dependent changes in brain structure. We chose to image fluorescently labelled cell nuclei, because these can be readily imaged in large tissue volumes and allow inferences on several structural parameters: (1) the physical volume as determined from a subset of nuclei used to generate a geometrically defined space, (2) the number of cells, (3) the nearest neighbour distance measured between all nuclei as an indicator of cell clustering, and (4) the volume of the cell nuclei. Using this approach, we found that physical volume did not significantly correlate with GMV change, whereas mean nuclear volume was inversely correlated. When focusing on layers within the imaging volume, positive correlations of GMV were found with cell number near the cortical surface and nearest neighbour distance in deeper layers. Thus, the novel approach introduced here provided new insights into the factors underlying grey matter volume changes.</p> | ||
| 700 | 1 | |a Falfán‐Melgoza, Claudia |e VerfasserIn |0 (DE-588)1156045177 |0 (DE-627)1018602879 |0 (DE-576)502002271 |4 aut | |
| 700 | 1 | |a Weber-Fahr, Wolfgang |d 1968- |e VerfasserIn |0 (DE-588)115518291X |0 (DE-627)1016515316 |0 (DE-576)501454578 |4 aut | |
| 700 | 1 | |a Beretta, Carlo Antonio |e VerfasserIn |0 (DE-588)1034706667 |0 (DE-627)746187238 |0 (DE-576)382338898 |4 aut | |
| 700 | 1 | |a Kuner, Thomas |e VerfasserIn |0 (DE-588)1074267966 |0 (DE-627)831945397 |0 (DE-576)442234562 |4 aut | |
| 700 | 1 | |a Knabbe, Johannes |e VerfasserIn |0 (DE-588)1156044022 |0 (DE-627)1018601619 |0 (DE-576)502001534 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t bioRxiv beta |d Cold Spring Harbor : Cold Spring Harbor Laboratory, NY, 2013 |g (2019) Artikel-Nummer 559765, 35 Seiten |h Online-Ressource |w (DE-627)783307497 |w (DE-600)2766415-6 |w (DE-576)404299903 |7 nnas |a Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach |
| 773 | 1 | 8 | |g year:2019 |g extent:35 |a Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach |
| 856 | 4 | 0 | |u https://doi.org/10.1101/559765 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.biorxiv.org/content/10.1101/559765v1 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210211 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1156044022 |a Knabbe, Johannes |m 1156044022:Knabbe, Johannes |d 910000 |d 910600 |e 910000PK1156044022 |e 910600PK1156044022 |k 0/910000/ |k 1/910000/910600/ |p 6 |y j | ||
| 998 | |g 1074267966 |a Kuner, Thomas |m 1074267966:Kuner, Thomas |d 50000 |d 53100 |e 50000PK1074267966 |e 53100PK1074267966 |k 0/50000/ |k 1/50000/53100/ |p 5 | ||
| 998 | |g 1034706667 |a Beretta, Carlo Antonio |m 1034706667:Beretta, Carlo Antonio |d 50000 |d 54600 |e 50000PB1034706667 |e 54600PB1034706667 |k 0/50000/ |k 1/50000/54600/ |p 4 | ||
| 998 | |g 115518291X |a Weber-Fahr, Wolfgang |m 115518291X:Weber-Fahr, Wolfgang |d 60000 |e 60000PW115518291X |k 0/60000/ |p 3 | ||
| 998 | |g 1226986676 |a Asan, Livia |m 1226986676:Asan, Livia |d 50000 |e 50000PA1226986676 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1748097024 |e 3851403762 | ||
| BIB | |a Y | ||
| JSO | |a {"title":[{"title":"Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach","title_sort":"Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach"}],"name":{"displayForm":["Livia Asan, Claudia Falfan-Melgoza, Wolfgang Weber-Fahr, Carlo Beretta, Thomas Kuner and Johannes Knabbe"]},"note":["Gesehen am 11.02.2021"],"person":[{"family":"Asan","role":"aut","display":"Asan, Livia","roleDisplay":"VerfasserIn","given":"Livia"},{"given":"Claudia","display":"Falfán‐Melgoza, Claudia","roleDisplay":"VerfasserIn","role":"aut","family":"Falfán‐Melgoza"},{"role":"aut","family":"Weber-Fahr","roleDisplay":"VerfasserIn","display":"Weber-Fahr, Wolfgang","given":"Wolfgang"},{"role":"aut","family":"Beretta","given":"Carlo Antonio","roleDisplay":"VerfasserIn","display":"Beretta, Carlo Antonio"},{"family":"Kuner","role":"aut","display":"Kuner, Thomas","roleDisplay":"VerfasserIn","given":"Thomas"},{"role":"aut","family":"Knabbe","roleDisplay":"VerfasserIn","display":"Knabbe, Johannes","given":"Johannes"}],"id":{"doi":["10.1101/559765"],"eki":["1748097024"]},"recId":"1748097024","relHost":[{"language":["eng"],"part":{"text":"(2019) Artikel-Nummer 559765, 35 Seiten","extent":"35","year":"2019"},"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"edited-book","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2013","publisherPlace":"Cold Spring Harbor","dateIssuedDisp":"2013-","publisher":"Cold Spring Harbor Laboratory, NY"}],"pubHistory":["2013 -"],"id":{"eki":["783307497"],"zdb":["2766415-6"]},"titleAlt":[{"title":"bio archive"}],"recId":"783307497","title":[{"subtitle":"the preprint server for biology","title_sort":"bioRxiv beta","title":"bioRxiv beta"}],"disp":"Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approachbioRxiv beta","note":["Gesehen am 14.04.2014"]}],"physDesc":[{"extent":"35 S."}],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"February 25, 2019"}],"type":{"bibl":"chapter","media":"Online-Ressource"},"language":["eng"]} | ||
| SRT | |a ASANLIVIAFGREYMATTER2520 | ||